dopamine (hydrochloride; Intropin - Discontinued in the US)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

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STORAGE: Dopamine injections are stored at room temperature between 20 C to 25 C (68 F to 77 F).

DOSING:

Adults

Dopamine is given by intravenous (IV) infusion.

  • Low dose: 1 to 5 mcg/kg/minute IV to increase urine output and kidney blood flow.
  • Intermediate dose: 5 to 15 mcg/kg/minute IV to increase kidney blood flow, cardiac output and contractility, and heart rate.
  • High dose: 20 to 50 mcg/kg/minute IV to increase blood pressure and stimulate vasoconstriction; may increase infusion by 1 to 4 mcg/kg/minute at 10 to 30 minute intervals until desired response (for example, adequate blood pressure) is achieved.

Safe and effective use of dopamine is not established in children.

DRUG INTERACTIONS: Dopamine should not be used in patients with pheochromocytoma and abnormal heart rate and rhythm.

Dopamine should not be used with medications like selegiline (Eldepryl, Zelapar), linezolid (Zyvox), and MAIO inhibitors like phenelzine (Nardil), isocarboxazid (Marplan) due to increased risk of a hypertensive episode.

Dopamine should not be used with tricyclic antidepressants (for example, amitriptyline [Elavil, Endep]) that increase dopamine and norepinephrine due to increased risk of hypertension and abnormal heart rate and rhythm.

PREGNANCY: There are no adequate studies done on dopamine to determine its safe and effective use in pregnant women.

NURSING MOTHERS: It is not known whether dopamine enters breast milk; therefore, it is best to be cautious before using it in nursing mothers.

Medically reviewed by Eni Williams, PharmD

REFERENCES:

FDA Prescribing Information.

Medscape. dopamine (Rx) - Intropin.

Medically Reviewed by a Doctor on 12/22/2015

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