dopamine (hydrochloride; Intropin - Discontinued in the US) (cont.)

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Dopamine is given by intravenous (IV) infusion.

  • Low dose: 1 to 5 mcg/kg/minute IV to increase urine output and kidney blood flow.
  • Intermediate dose: 5 to 15 mcg/kg/minute IV to increase kidney blood flow, cardiac output and contractility, and heart rate.
  • High dose: 20 to 50 mcg/kg/minute IV to increase blood pressure and stimulate vasoconstriction; may increase infusion by 1 to 4 mcg/kg/minute at 10 to 30 minute intervals until desired response (for example, adequate blood pressure) is achieved.

Safe and effective use of dopamine is not established in children.

DRUG INTERACTIONS: Dopamine should not be used in patients with pheochromocytoma and abnormal heart rate and rhythm.

Dopamine should not be used with medications like selegiline (Eldepryl, Zelapar), linezolid (Zyvox), and MAIO inhibitors like phenelzine (Nardil), isocarboxazid (Marplan) due to increased risk of a hypertensive episode.

Dopamine should not be used with tricyclic antidepressants (for example, amitriptyline [Elavil, Endep]) that increase dopamine and norepinephrine due to increased risk of hypertension and abnormal heart rate and rhythm.

PREGNANCY: There are no adequate studies done on dopamine to determine its safe and effective use in pregnant women.

NURSING MOTHERS: It is not known whether dopamine enters breast milk; therefore, it is best to be cautious before using it in nursing mothers.

Medically Reviewed by a Doctor on 6/16/2014

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