dopamine (hydrochloride; Intropin - Discontinued in the US) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

SIDE EFFECTS: Side effects of dopamine may include:

  • increased heart rate,
  • abnormal heart rhythm,
  • increased or decreased blood pressure,
  • disordered breathing,
  • nausea,
  • vomiting,
  • headache, and
  • increased blood urea nitrogen.



PREPARATIONS: Additive solutions for IV infusion: 40, 80, 160 mg/ml. Infusion Solution: 80, 160, 320, mg/100 ml

STORAGE: Dopamine injections are stored at room temperature between 20 C to 25 C (68 F to 77 F).



Dopamine is given by intravenous (IV) infusion.

  • Low dose: 1 to 5 mcg/kg/minute IV to increase urine output and kidney blood flow.
  • Intermediate dose: 5 to 15 mcg/kg/minute IV to increase kidney blood flow, cardiac output and contractility, and heart rate.
  • High dose: 20 to 50 mcg/kg/minute IV to increase blood pressure and stimulate vasoconstriction; may increase infusion by 1 to 4 mcg/kg/minute at 10 to 30 minute intervals until desired response (for example, adequate blood pressure) is achieved.

Safe and effective use of dopamine is not established in children.

DRUG INTERACTIONS: Dopamine should not be used in patients with pheochromocytoma and abnormal heart rate and rhythm.

Dopamine should not be used with medications like selegiline (Eldepryl, Zelapar), linezolid (Zyvox), and MAIO inhibitors like phenelzine (Nardil), isocarboxazid (Marplan) due to increased risk of a hypertensive episode.

Dopamine should not be used with tricyclic antidepressants (for example, amitriptyline [Elavil, Endep]) that increase dopamine and norepinephrine due to increased risk of hypertension and abnormal heart rate and rhythm.

Medically Reviewed by a Doctor on 12/22/2015

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