Common side effects of dopamine include
Serious side effects of dopamine include
- abnormal heart rhythm,
- increased or decreased blood pressure,
- increased pressure in the eye, and
- gangrene in the extremities.
DOSAGE FOR ADULTS:
Dopamine is given by intravenous (IV) infusion.
- Low dose: 1 to 5 mcg/kg/minute IV to increase urine output and kidney blood flow.
- Intermediate dose: 5 to 15 mcg/kg/minute IV to increase kidney blood flow, cardiac output and contractility, and heart rate.
- High dose: 20 to 50 mcg/kg/minute IV to increase blood pressure and stimulate vasoconstriction; may increase infusion by 1 to 4 mcg/kg/minute at 10 to 30 minute intervals until desired response (for example, adequate blood pressure) is achieved.
Safe and effective use of dopamine is not established in children.
- Dopamine should not be used in patients with pheochromocytoma and abnormal heart rate and rhythm.
- Dopamine should not be used with medications like selegiline (Eldepryl, Zelapar), linezolid (Zyvox), and MAIO inhibitors like phenelzine (Nardil), isocarboxazid (Marplan) due to increased risk of a hypertensive episode.
- Dopamine should not be used with tricyclic antidepressants (for example, amitriptyline [Elavil, Endep]) that increase dopamine and norepinephrine due to increased risk of hypertension and abnormal heart rate and rhythm.
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