dopamine (hydrochloride; Intropin - Discontinued in the US)

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GENERIC NAME: dopamine hydrochloride

BRAND NAME: Intropin (discontinued in the US)

DRUG CLASS AND MECHANISM: Dopamine is a chemical produced by our body and it has several functions. Dopamine works as a neurotransmitter (chemical that nerves use to communicate) in the brain. It is also converted to norepinephrine, another neurotransmitter. Dopamine increases heart rate and heart muscle contractions. It also causes increases in blood pressure. The FDA approved dopamine in February 1974.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Additive solutions for IV infusion: 40, 80, 160 mg/ml. Infusion Solution: 80, 160, 320, mg/100 ml

STORAGE: Dopamine injections are stored at room temperature between 20 C to 25 C (68 F to 77 F).

PRESCRIBED FOR: Dopamine is prescribed to correct hemodynamic status in patients with shock syndrome due to heart attack (myocardial infarction), trauma, open-heart surgery, renal failure, congestive heart failure, and other causes of shock syndrome. This means dopamine may be capable of improving urine flow, blood pressure, blood flow to vital organs, and improving heart function in patients with shock syndrome.

DOSING:

Adults

Dopamine is given by intravenous (IV) infusion.

  • Low dose: 1 to 5 mcg/kg/minute IV to increase urine output and kidney blood flow.
  • Intermediate dose: 5 to 15 mcg/kg/minute IV to increase kidney blood flow, cardiac output and contractility, and heart rate.
  • High dose: 20 to 50 mcg/kg/minute IV to increase blood pressure and stimulate vasoconstriction; may increase infusion by 1 to 4 mcg/kg/minute at 10 to 30 minute intervals until desired response (for example, adequate blood pressure) is achieved.
Medically Reviewed by a Doctor on 6/16/2014



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