DOSING: The initial dose for adults is based on the indication and severity of heart failure. Dosing is 0.5 to 1 micrograms per kilogram body weight per minute followed by an intravenous infusion of 2 to 20 micrograms per kilogram body weight per minute. Maximum dose is 40 micrograms per kilogram per minute.
DRUG INTERACTIONS: Use caution when combining dobutamine with other agents that increase heart rate or blood pressure (sympathomimetics), such as atomoxetine (Strattera), dopamine, and epinephrine. Use lower doses of dobutamine initially if the patient is also on linezolid (Zyvox) as there is a risk of significant increase in blood pressure. Calcium salts may decrease the effect of dobutamine, so monitor closely.
PREGNANCY: Available evidence suggests that dobutamine may be safely used in pregnancy.
NURSING MOTHERS: Dobutamine should be used cautiously by nursing mothers as it is unknown whether it is excreted in breast milk.
Medically reviewed by Eni Williams, PharmD
REFERENCE: FDA Prescribing Information.
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