dobutamine (injection; Dobutrex) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

DRUG INTERACTIONS: Use caution when combining dobutamine with other agents that increase heart rate or blood pressure (sympathomimetics), such as atomoxetine (Strattera), dopamine, and epinephrine. Use lower doses of dobutamine initially if the patient is also on linezolid (Zyvox) as there is a risk of significant increase in blood pressure. Calcium salts may decrease the effect of dobutamine, so monitor closely.

PREGNANCY: Available evidence suggests that dobutamine may be safely used in pregnancy.

NURSING MOTHERS: Dobutamine should be used cautiously by nursing mothers as it is unknown whether it is excreted in breast milk.

SIDE EFFECTS: The most frequent adverse reactions include increased heart rate, increased blood pressure, irregular ventricular beats, and chest pain. Fever, headache, nausea, low blood pressure, and shortness of breath have also been reported.

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 6/26/2014

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