- The initial dose for adults is based on the indication and severity of heart failure.
- Dosing is 0.5 to 1 micrograms per kilogram body weight per minute followed by an intravenous infusion of 2 to 20 micrograms per kilogram body weight per minute.
- Maximum dose is 40 micrograms per kilogram per minute.
- Use caution when combining dobutamine with other agents that increase heart rate or blood pressure (sympathomimetics), such as atomoxetine (Strattera), dopamine, and epinephrine.
- Use lower doses of dobutamine initially if the patient is also on linezolid (Zyvox) as there is a risk of significant increase in blood pressure.
- Calcium salts may decrease the effect of dobutamine, so monitor closely.
PREGNANCY AND BREASTFEEDING SAFETY:
- Available evidence suggests that dobutamine may be safely used in pregnancy.
- Dobutamine should be used cautiously by nursing mothers as it is unknown whether it is excreted in breast milk.
Quick GuideHeart Disease: Symptoms, Signs, and Causes
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