dobutamine (injection; Dobutrex has been discontinued)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

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Is dobutamine-injection available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for dobutamine-injection?

Yes

What are the uses for dobutamine-injection?

  • Dobutamine is prescribed to help increase cardiac output in a failing heart due to heart disease or cardiac surgery.

What are the side effects of dobutamine-injection?

The most frequent adverse reactions include

  • increased heart rate,
  • increased blood pressure,
  • irregular ventricular beats, and
  • chest pain.

Other important side effects include

Serious side effects of dobutamine include

  • abnormal heart beats,
  • increased heart rate,
  • low blood pressure,
  • chest pain,
  • fainting , and
  • eosinophilic myocarditis.

Quick GuideHeart Disease: Symptoms, Signs, and Causes

Heart Disease: Symptoms, Signs, and Causes

What is the dosage for dobutamine-injection?

  • The initial dose for adults is based on the indication and severity of heart failure.
  • Dosing is 0.5 to 1 micrograms per kilogram body weight per minute followed by an intravenous infusion of 2 to 20 micrograms per kilogram body weight per minute.
  • Maximum dose is 40 micrograms per kilogram per minute.

Which drugs or supplements interact with dobutamine-injection?

  • Use caution when combining dobutamine with other agents that increase heart rate or blood pressure (sympathomimetics), such as atomoxetine (Strattera), dopamine, and epinephrine.
  • Use lower doses of dobutamine initially if the patient is also on linezolid (Zyvox) as there is a risk of significant increase in blood pressure.
  • Calcium salts may decrease the effect of dobutamine, so monitor closely.

Is dobutamine-injection safe to take if I'm pregnant or breastfeeding?

  • Available evidence suggests that dobutamine may be safely used in pregnancy.
  • Dobutamine should be used cautiously by nursing mothers as it is unknown whether it is excreted in breast milk.

What else should I know about dobutamine-injection?

What preparations of dobutamine-injection are available?

Intravenous solution: 250, 500, 1000 mg in 250 mL, 250 mg in 20 mL, 500 mg in 40 mL

How should I keep dobutamine-injection stored?

  • Vials should be stored at room temperature, between 15 C to 30 C (59 F to 86 F).
  • Once diluted, dobutamine may be stored in the refrigerator (4 C) for 7 days or up to 48 hours at room temperature.

REFERENCE: FDA Prescribing Information.

Last Editorial Review: 9/21/2016

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Reviewed on 9/21/2016
References
REFERENCE: FDA Prescribing Information.

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