dobutamine (injection; Dobutrex)

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GENERIC NAME: dobutamine injection

BRAND NAMES: Dobutrex (Brand name is no longer available in the US)

DRUG CLASS AND MECHANISM: Dobutamine is a synthetic drug that stimulates receptors (beta-1 receptors) on the heart. It is classified as a catecholamine. Other catecholamines include epinephrine, dopamine, and isoproterenol. Stimulating beta-1 receptors receptor causes an increase in the force of the heart's contraction, therefore increasing cardiac output which is the amount of blood pumped by the heart. Unlike other catecholamines, dobutamine has minimal effects on heart rate, which helps to decrease the chance of irregular heartbeats. Dobutamine does not have significant effects on blood pressure. The FDA approved dobutamine in July 1978.

SIDE EFFECTS: The most frequent adverse reactions include increased heart rate:

  • increased blood pressure,
  • irregular ventricular beats, and
  • chest pain.
Medically Reviewed by a Doctor on 9/28/2015

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