dobutamine (injection; Dobutrex)

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GENERIC NAME: dobutamine injection

BRAND NAMES: Dobutrex (Brand name is no longer available in the US)

DRUG CLASS AND MECHANISM: Dobutamine is a synthetic drug that stimulates receptors (beta-1 receptors) on the heart. It is classified as a catecholamine. Other catecholamines include epinephrine, dopamine, and isoproterenol. Stimulating beta-1 receptors receptor causes an increase in the force of the heart's contraction, therefore increasing cardiac output which is the amount of blood pumped by the heart. Unlike other catecholamines, dobutamine has minimal effects on heart rate, which helps to decrease the chance of irregular heartbeats. Dobutamine does not have significant effects on blood pressure. The FDA approved dobutamine in July 1978.



PREPARATIONS: Intravenous solution: 250, 500, 1000 mg in 250 mL, 250 mg in 20 mL, 500 mg in 40 mL

STORAGE: Vials should be stored at room temperature, between 15 C to 30 C (59 F to 86 F). Once diluted, dobutamine may be stored in the refrigerator (4 C) for 7 days or up to 48 hours at room temperature.

PRESCRIBED FOR: Dobutamine is prescribed to help increase cardiac output in a failing heart due to heart disease or cardiac surgery.

DOSING: The initial dose for adults is based on the indication and severity of heart failure. Dosing is 0.5 to 1 micrograms per kilogram body weight per minute followed by an intravenous infusion of 2 to 20 micrograms per kilogram body weight per minute. Maximum dose is 40 micrograms per kilogram per minute.

Medically Reviewed by a Doctor on 6/26/2014

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