disulfiram, Antabuse

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Prescription Drug Abuse Statistics

GENERIC NAME: disulfiram

BRAND NAME: Antabuse



USES: Disulfiram is used of treating alcoholism. It is used in combination with supportive care and psychotherapy.

Disulfiram should never be given to a patient who is intoxicated, or without his or her full knowledge. Relatives of patients should be advised about this warning also.

Patients should be fully informed about the disulfiram-alcohol reaction and must be strongly warned about drinking while taking disulfiram. Patients should avoid alcohol in all forms, including alcohol in sauces, vinegars, cough mixtures, mouth wash, aftershave lotions, and back rubs.

Disulfiram may cause a reaction with alcohol up to 14 days after ingestion.

Disulfiram should be used cautiously in patients with diabetes, hypothyroidism, epilepsy, cerebral damage, nephritis, and hepatic impairment.

Disulfiram should not be given to people with severe heart disease, people allergic to disulfiram, and people with psychosis.


When alcohol is consumed by a patient taking disulfiram, effects include:

Common side effects of disulfiram include:

Possible serious side effects of disulfiram include:

Medically Reviewed by a Doctor on 1/19/2016

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