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- What is diphenoxylate and atropine, and how does it work (mechanism of action)?
- What brand names are available for diphenoxylate and atropine?
- Is diphenoxylate and atropine available as a generic drug?
- Do I need a prescription for diphenoxylate and atropine?
- What are the side effects of diphenoxylate and atropine?
- What is the dosage for diphenoxylate and atropine?
- Which drugs or supplements interact with diphenoxylate and atropine?
- Is diphenoxylate and atropine safe to take if I'm pregnant or breastfeeding?
- What else should I know about diphenoxylate and atropine?
What is diphenoxylate and atropine, and how does it work (mechanism of action)?
Lomotil is a combination of two drugs, diphenoxylate and atropine. It is used to treat acute diarrhea (diarrhea of limited duration). Diphenoxylate is a man-made narcotic chemically related to meperidine (Demerol). Like other narcotics, diphenoxylate reduces diarrhea by interfering with the propulsion of intestinal contents through the intestines. Although diphenoxylate is chemically related to narcotics, it does not have pain- relieving (analgesic) actions like most other narcotics. In higher doses, however, like other narcotics, diphenoxylate can cause euphoria (elevation of mood) and physical dependence. In order to prevent abuse of diphenoxylate for its mood-elevating effects, atropine is combined with diphenoxylate in small quantities. As a result, if Lomotil is taken in greater than recommended doses unpleasant side effects from too much atropine will occur. Lomotil was approved by the FDA in 1960.
What brand names are available for diphenoxylate and atropine?
Lomotil, Lofene, Lonox
Is diphenoxylate and atropine available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for diphenoxylate and atropine?
What are the side effects of diphenoxylate and atropine?
The most common side effects reported in persons taking diphenoxylate include:
Other important side effects include:
- numbness of extremities,
- loss of
- appetite, and
- abdominal pain.
Although the dose of atropine in Lomotil is too low to cause side effects when taken in the recommended doses, side effects of atropine (including dryness of the skin and mucous membranes, increased heart rate, urinary retention, and increased body temperature) have been reported, particularly in children under two years of age and children with Down syndrome. Pancreatitis and toxic megacolon also have been reported.
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