GENERIC NAME: diphenoxylate and atropine
BRAND NAME: Lomotil, Lofene, Lonox
DRUG CLASS AND MECHANISM: Lomotil is a combination of two drugs, diphenoxylate and atropine. It is used to treat acute diarrhea (diarrhea of limited duration). Diphenoxylate is a man-made narcotic chemically related to meperidine (Demerol). Like other narcotics, diphenoxylate reduces diarrhea by interfering with the propulsion of intestinal contents through the intestines. Although diphenoxylate is chemically related to narcotics, it does not have pain- relieving (analgesic) actions like most other narcotics. In higher doses, however, like other narcotics, diphenoxylate can cause euphoria (elevation of mood) and physical dependence. In order to prevent abuse of diphenoxylate for its mood-elevating effects, atropine is combined with diphenoxylate in small quantities. As a result, if Lomotil is taken in greater than recommended doses unpleasant side effects from too much atropine will occur. Lomotil was approved by the FDA in 1960.
PRESCRIBED FOR: Lomotil is used for the relief of acute diarrhea.
SIDE EFFECTS: The most common side effects reported in persons taking diphenoxylate include:
Quick GuideDigestive Disorders: Common Misconceptions
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