diphenhydramine, Benadryl (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
STORAGE: Diphenhydramine should be stored at room temperature, 15 C to 30 C (59 F to 86 F), and the injection should be protected from freezing and light.
DOSING: Diphenhydramine doses vary depending on formulation, and has its maximal effect about one hour after it is taken.
Diphenhydramine adds to (exaggerates) the sedating effects of alcohol and other drugs than can cause sedation such as the benzodiazepine class of anti-anxiety (for example, diazepam [Valium], lorazepam [Ativan], clonazepam [Klonopin], alprazolam [Xanax]), the narcotic class of pain medications and its derivatives (for example, oxycodone and acetaminophen [Percocet], and hydrocodone and acetaminophen [Vicodin], guaifenesin with hydromorphone [Dilaudid], codeine, propoxyphene [Darvon]), the tricyclic class of antidepressants (for example, amitriptyline [Elavil, Endep], imipramine [Tofranil], desipramine [Norpramin]), and certain antihypertensive medications (for example, clonidine [Catapres], propranolol [Inderal]). Diphenhydramine also can intensify the drying effects of other medications with anticholinergic properties (for example, dicyclomine [Bentyl] and bethanechol [Urecholine], probanthine).
Medically Reviewed by a Doctor on 3/27/2015
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