dimenhydrinate-ergotamine-caffeine oral (cont.)

SIDE EFFECTS: Stomach upset, nausea, vomiting, drowsiness, nervousness, frequent urination or constipation may occur. If any of these effects persist or worsen, notify your doctor promptly. Report promptly: muscle pain, weakness in the legs, tingling or pain in the fingers or toes, fast/irregular heartbeat, blurred vision, dry mouth, painful urination. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Tell your doctor your medical history, especially of: liver disease, kidney disease, heart disease, chest pain (angina), high blood pressure, blood vessel disease, poor circulation, glaucoma, prostate trouble, ulcers, severe infection, any allergies, sensitivity to caffeine. Avoid the use of alcohol while taking this medication. Caution is advised when performing tasks requiring alertness (e.g., driving), since this medication may cause drowsiness. This medication should not be used during pregnancy. If you become pregnant or think you may be pregnant, inform your doctor immediately. It is not known if this medication passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Infrequently, a very serious, life-threatening decrease in the amount of blood supply to the hands and feet (peripheral ischemia) and rarely to the brain can occur when this medication is taken with drugs that affect liver metabolism (e.g., potent CYP 3A4 enzyme inhibitors). Do not take this medication with macrolide antibiotics (e.g., erythromycin, clarithromycin, troleandomycin), protease inhibitors (e.g., ritonavir, nelfinavir, indinavir, amprenavir, saquinavir), azole antifungals (e.g., ketoconazole, itraconazole). Tell your doctor of any prescription or nonprescription medication you may take including: blood pressure medications, nitrates (e.g., isosorbide, nitroglycerin), nefazodone, fluconazole, fluoxetine, fluvoxamine, zileuton, clotrimazole, other mild CYP 3A4 enzyme inhibitors. Tell your doctor if you take any drugs that make you drowsy, such as: sedatives, tranquilizers, narcotic pain relievers (e.g., codeine), muscle relaxants, certain antihistamines (e.g., diphenhydramine). Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor instructs you otherwise. Avoid drinking caffeine-containing beverages (coffee, tea, colas) and eating large amounts of chocolate. Because this medication contains caffeine, the risk of side effects may be increased. Also, check labels carefully, as many products may contain antihistamines (e.g., cough-and-cold products). Do not start or stop any medicine without doctor or pharmacist approval.

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