diltiazem (Cardizem, Cardizem CD, Cardizem LA, Dilacor XR, Tiazac, Cartia XT and several others) (cont.)

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Medical and Pharmacy Editor:
Medical and Pharmacy Editor:

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS:

  • Tablets (immediate release): 30, 60, 90, and 120 mg.
  • Tablets (extended release): 120, 180, 240, 300, 360, 420 mg.
  • Capsules (extended release): 120, 180, 240, 300, 360, 420 mg.
  • Injection: 5 mg/ml. Powder for injection: 100 mg.
  • Injectable Solution: 5, 10, 50, 125 mg/ml.

STORAGE: Tablets, capsules and powder for injection should be stored at room temperature, 15 C and 30 C (59 F and 86 F). Solution for injection should be stored at 2 C and 8 C (36 F and 46 F).

PRESCRIBED FOR: Diltiazem is used for treating heart pain (angina), high blood pressure, and abnormal heart rhythms such as atrial fibrillation, atrial flutter and paroxysmal supraventricular tachycardia.

DOSING:

  • Adult oral doses for chest pain or high blood pressure (hypertension) range between 120 and 540 mg daily. Dosing varies depending on formulation and use.
  • Immediate release tablets are administered up to 4 times a day.
  • Extended release formulations are administered once daily at approximately the same time each day and should not be crushed or chewed.
  • Injectable forms are used for treating atrial fibrillation, atrial flutter and paroxysmal supraventricular tachycardia.

DRUG INTERACTIONS: Administration of diltiazem with digoxin (Lanoxin) can increase digoxin blood levels. Therefore, blood levels of digoxin usually are monitored to avoid toxicity from digoxin. Similarly, concurrent administration of diltiazem with an anti-seizure medication, carbamazepine (Tegretol), can increase blood levels of the seizure medication, and occasionally lead to toxicity. Diltiazem increases blood levels of lovastatin (Mevacor), atorvastatin (Lipitor) and simvastatin (Zocor), possibly increasing the risk of adverse effects. Diltiazem may increase blood levels of buspirone (Buspar), midazolam (Versed), triazolam (Halcion) and diazepam (Valium) by reducing their breakdown and elimination from the body by the liver. This can lead to toxicity from these drugs. Rifampin (Rifamate, Rifadin, Rimactane) reduces the effect of diltiazem by reducing its levels in blood to undetectable levels.

Medically Reviewed by a Doctor on 8/7/2014


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