What other names is Diindolylmethane known by?

Diindolymetano, Diidolylméthane, DIM, 3,3'-Diindolylmethane.

What is Diindolylmethane?

Diindolylmethane is formed in the body from plant substances contained in "cruciferous" vegetables such as cabbage, Brussels sprouts, cauliflower, and broccoli. Scientists think these vegetables may help to protect the body against cancer because they contain diindolylmethane and a related chemical called indole-3-carbinol.

Diindolylmethane is used for preventing breast, uterine, and colorectal cancer. It is also used to prevent an enlarged prostate (benign prostatic hypertrophy, BPH) and treat premenstrual syndrome (PMS).

Insufficient Evidence to Rate Effectiveness for...

  • Abnormal growth of cells of the cervix (cervical dysplasia). Early research suggests that taking a specific diindolylmethane product (BioResponse-DIM by BioResponse) for 12 weeks does not improve markers of disease in women with cervical dysplasia.
  • Prostate cancer. Early research suggest that taking a specific diindolylmethane product (BioResponse-DIM) for 28 days lowers prostate-specific antigen (PSA) levels in men with prostate cancer. PSA levels can be used to measure the progress of prostate cancer.
  • Preventing breast cancer.
  • Preventing uterine cancer.
  • Preventing colon cancer.
  • Preventing prostate enlargement (benign prostatic hypertrophy, BPH).
  • Treating premenstrual syndrome (PMS).
  • Other conditions.
More evidence is needed to rate the effectiveness of diindolylmethane for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

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