- Take the Tummy Trouble Quiz
- Boost Digestive Health
- Digestive Distress Slideshow: Problem Foods to Avoid
- What are oral digestive enzymes?
- What diseases and conditions are treated with oral digestive enzymes (PEPs)?
- Are oral digestive enzymes available by prescription and over-the-counter (OTC)?
- What are examples of prescription oral digestive enzymes available in the US?
- What are the side effects of oral digestive enzymes?
- What drugs interact with oral digestive enzymes?
- What formulations of oral digestive enzymes are available?
- Are taking oral digestive enzymes during pregnancy or while breastfeeding safe?
What are the side effects of oral digestive enzymes?
Although rare, some patients can experience life-threatening allergic reactions when taking this medicine. Patients should stop their medication immediately and seek emergency medical help if they have any of the following signs or symptoms.
- Difficulty breathing or talking
- Swelling of the mouth, face, lips, tongue, or throat
- Chest tightness
- Rash or hives
- Red, swollen, blistered, or peeling skin
Other side effects of digestive enzymes include:
- Stomach pain
- Sore throat
- Upset stomach
- Nausea or vomiting
- Neck pain
- Stuffy nose
- Ear pain
This medication can increase the risk of developing a rare but serious bowel problem called fibrosing colonopathy in which there is localized inflammation and scarring in the colon. Patients are advised to call their doctor right away if they have very bad
Many digestive enzymes are derived from pork and therefore, should not be used by patients who are allergic to pork.
What drugs interact with oral digestive enzymes?
The effectiveness of oral digestive enzymes may decrease when they are given with calcium or magnesium containing antacids.
Digestive enzymes containing amylase or other carbohydrate digesting enzymes may reduce the effectiveness of alpha-glucosidase inhibitors (for example, acarbose (Precose), miglitol [Glyset]), a class of oral anti-diabetes medications that are used to reduce the activity of the carbohydrate digesting enzymes.
Quick GuideDigestive Disorders: Common Misconceptions
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Use the pill identifier tool on RxList.