- Take the Tummy Trouble Quiz
- Boost Digestive Health
- Digestive Distress Slideshow: Problem Foods to Avoid
- What are oral digestive enzymes?
- What diseases and conditions are treated with oral digestive enzymes (PEPs)?
- Are oral digestive enzymes available by prescription and over-the-counter (OTC)?
- What are examples of prescription oral digestive enzymes available in the US?
- What are the side effects of oral digestive enzymes?
- What drugs interact with oral digestive enzymes?
- What formulations of oral digestive enzymes are available?
- Are taking oral digestive enzymes during pregnancy or while breastfeeding safe?
Are oral digestive enzymes available by prescription and over-the-counter (OTC)?
Digestive enzymes are available over-the-counter (OTC) or by prescription.
- OTC products are not approved by the FDA and should not be used with the intent to cure or treat any aliments.
- OTC digestive enzymes are mainly used as a dietary supplements to help with digestion.
- OTC dietary supplements are not regulated by the FDA and may contain impurities and varying quantities of active ingredients.
A person should speak to their doctor or pharmacist if he/she is interested in starting an OTC regimen.
Prescription digestive enzymes come in various formulations and may contain different amounts of individual digestive enzymes. Therefore, prescription digestive enzymes are not clinically interchangeable and are not considered bioequivalent by the FDA.
What are examples of prescription oral digestive enzymes available in the US?
- Pancreatin (Ku-Zyme, Kutrase, Lapase)
- Pancrelipase (Cotazym S, Creon
- Creon (Lipase 24,000 unit)
- Creon (Lipase 3,000 unit)
- Creon (Lipase 12,000 unit)
- Creon (Lipase 6,000 unit)
- Creon 10
- Creon 20
- Creon 5
- Ku-Zyme HP
- Lipram 10,000
- Pancrease MT 10
- Pancrease MT 16
- Pancrease MT 20
- Pancrease MT 4
- Pancrecarb MS-16
- Pancrecarb MS-4
- Pancrecarb MS-8
- Pancron 10
- Pancron 20
- Pangestyme CN 10
- Pangestyme CN 20
- Pangestyme EC
- Pangestyme MT16
- Pangestyme UL12
- Pangestyme UL18
- Pangestyme UL20
- Panocaps MT-16
- Panocaps MT-20
- Panokase 16
- Ultracaps MT-20
- Ultrase MT 12
- Ultrase MT 18
- Ultrase MT20
- Zenpep (Lipase 10,000 unit)
- Zenpep (Lipase 15,000 unit)
- Zenpep (Lipase 20,000 unit)
- Zenpep (Lipase 25,000 unit)
- Zenpep (Lipase 3,000 unit)
- Zenpep (Lipase 5,000 unit)
Quick GuideDigestive Disorders: Common Misconceptions
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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Use the pill identifier tool on RxList.