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- What is diflunisal, and how does it work (mechanism of action)?
- What brand names are available for diflunisal?
- Is diflunisal available as a generic drug?
- Do I need a prescription for diflunisal?
- What are the side effects of diflunisal?
- What is the dosage for diflunisal?
- Which drugs or supplements interact with diflunisal?
- Is diflunisal safe to take if I'm pregnant or breastfeeding?
- What else should I know about diflunisal?
What is the dosage for diflunisal?
For mild to moderate pain, an initial dose of 500 to 1000 mg followed by 250 to 500 mg every 12 hours is recommended for most patients. For osteoarthritis and rheumatoid arthritis, the suggested dosage range is 250 mg to 500 mg twice daily. The maximum dose is 1.5 g/day. Tablets should be swallowed whole, not chewed. Dosing under the age of 12 has not been determined.
Which drugs or supplements interact with diflunisal?
: Concomitant use of NSAIDs with angiotensin-converting enzyme (ACE) inhibitors such as enalapril (Vasotec) or angiotensin II receptor antagonists (ARBs) such as irbesartan (Avapro) may reduce the blood pressure response to the antihypertensive agent since prostaglandins are important in controlling blood pressure.
When diflunisal is used in combination with methotrexate (Rheumatrex, Trexall), the blood levels of methotrexate may increase, presumably because the elimination from the body is reduced. This may lead to more methotrexate related side effects.
Individuals taking oral blood thinners or anticoagulants, for example, warfarin, (Coumadin) should avoid diflunisal because diflunisal also thins the blood, and excessive blood thinning may lead to bleeding.
Persons who have more than three alcoholic beverages per day may be at increased risk of developing stomach ulcers when taking dilfunisal or other NSAIDs.
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