- Rheumatoid Arthritis Slideshow Pictures
- Joint-Friendly Exercises to Reduce RA Pain Slideshow
- Take the RA Quiz
- What is diflunisal, and how does it work (mechanism of action)?
- What brand names are available for diflunisal?
- Is diflunisal available as a generic drug?
- Do I need a prescription for diflunisal?
- What are the side effects of diflunisal?
- What is the dosage for diflunisal?
- Which drugs or supplements interact with diflunisal?
- Is diflunisal safe to take if I'm pregnant or breastfeeding?
- What else should I know about diflunisal?
What is diflunisal, and how does it work (mechanism of action)?
Diflunisal is a nonsteroidal anti-inflammatory drug (NSAID) that is effective in treating fever, pain, and inflammation in the body. Other members of this class include ibuprofen (Motrin), indomethacin (Indocin), nabumetone (Relafen), naproxen (Anaprox, Naprosyn, Aleve) and several others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins, chemicals that are responsible for pain, fever, and inflammation. Diflunisal blocks the enzymes that make prostaglandins (cyclooxygenases), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced. Diflunisal was approved by the FDA in April 1982.
What brand names are available for diflunisal?
Dolobid (This brand is no longer available in the U.S.)
Is diflunisal available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for diflunisal?
What are the side effects of diflunisal?
Most patients benefit from diflunisal and other NSAIDs with few side effects. However, serious side effects can occur and generally tend to be seen at higher doses. Therefore, it is often desirable to use the lowest effective dose to minimize side effects. The most common side effects of diflunisal involve the gastrointestinal system. It can cause ulcerations, abdominal burning, pain, cramping, nausea, gastritis, and even serious gastrointestinal bleeding and liver toxicity. Sometimes, stomach ulceration and bleeding can occur without any abdominal pain. Black tarry stools, weakness, and dizziness upon standing may be the only signs of internal bleeding. Rash, kidney impairment, ringing in the ears, and lightheadedness also may occur.
Quick GuideLyme Disease Symptoms, Rash, Treatments
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Use the pill identifier tool on RxList.