PRECAUTIONS: Tell your doctor your medical history, especially of: pancreatic disease, tingling of the hands or feet (called peripheral neuropathy), kidney problems, heart problems, liver problems, a sodium-restricted diet, major surgery/infection/in- jury, alcohol use, gall bladder problems, stomach problems, vision problems, high fats in the blood (triglycerides), allergies (especially drug allergies). Avoid alcoholic beverages because they may worsen pancreatitis. Before using didanosine, tell your doctor if you are pregnant. It is not known if didanosine passes into breast milk. Because breast milk can pass HIV infection, do not breast-feed.

DRUG INTERACTIONS: This drug should not be used with the following medications because very serious interactions may occur: allopurinol, ribavirin. If you are currently using any of these medications, tell your doctor or pharmacist before starting didanosine. Tell your doctor of all prescription and nonprescription drugs you may use, especially of: benzodiazepines (e.g., diazepam, triazolam), delavirdine, drugs that decrease stomach acid (e.g., cimetidine, omeprazole), ganciclovir, protease inhibitors (e.g., indinavir, nelfinavir, ritonavir), tenofovir, methadone, stavudine, zalcitabine, zidovudine. Also, report the use of drugs that may increase the risk of pancreatitis (e.g., pentamidine or sulfonamides such as cotrimoxazole). Consult your doctor or pharmacist. Do not use dapsone, itraconazole, ketoconazole within 2 hours of this medication. Food decreases the absorption of this drug. Follow your doctor's advice about food and the use of this drug. Do not start or stop any medicine without doctor or pharmacist approval.

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