didanosine, Videx, Videx EC (cont.)

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Medical and Pharmacy Editor:

GENERIC AVAILABLE: Yes

PRESCRIPTION: Yes

PREPARATIONS: Capsules (Extended Release): 125, 200, 250, and 400 mg. Solution: 10 mg/ml

STORAGE: Capsules and unmixed powder should be stored at room temperature, 15 C to 30 C (59 F to 86 F). The powder may be stored in the refrigerator at 2 C to 8 C (36 F to 46 F for up to 30 days after it is mixed with water.

PRESCRIBED FOR: Didanosine is used for the treatment of HIV infection in adults and children.

DOSING: Adults weighing 60 kg or more should receive 400 mg once daily of the capsules or 200 mg twice daily of the powder. Adults weighing less than 60 kg require 250 mg once daily of the capsules and 125 mg twice daily of the powder.

Didanosine should be administered on an empty stomach because food reduces the absorption of didanosine by as much as 46%.

DRUG INTERACTIONS: Didanosine powder contains an antacid which reduces the absorption of tetracycline (for example, Vibramycin, Minocin), ketoconazole (Nizoral), fluoroquinolone antibiotics (for example, ciprofloxacin [Cipro], Floxin), and other drugs that need stomach acid for absorption. Therefore, these drugs should be administered at least two hours before or after administration of didanosine solution.

Allopurinol (Zyloprim), tenofovir (Viread), and ganciclovir (Cytovene) increase blood levels of didanosine by reducing its elimination.

PREGNANCY: Use of didanosine during pregnancy has not been adequately evaluated.

NURSING MOTHERS: Although it is not known whether didanosine is excreted in breast milk, HIV-infected mothers should not breast feed because of the potential risk of transmitting HIV to an infant that is not infected.

SIDE EFFECTS: The most severe side effects of didanosine are inflammation of the pancreas (pancreatitis), liver failure and nerve damage in the arms and legs (peripheral neuropathy). Symptoms of peripheral neuropathy are tingling, numbness and pain in the feet or hands. Other side effects include diarrhea, chills, fever, rash, stomach pain, headache, nausea and vomiting.

Reference: FDA Prescribing Information


Medically Reviewed by a Doctor on 3/8/2013


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