The combined effects of these drugs can lead to a greater incidence of
- dry mouth,
- blurred vision,
- increased heart rate,
- constipation, and
- urinary retention (difficulty urinating).
Combining narcotics such as oxycodone (Percocet, Percodan), hydrocodone (Vicodin) with dicyclomine may reduce function of the muscles of the bowel and bladder resulting in greater constipation and difficulty urinating than with dicyclomine alone. Combining dicyclomine with pramlintide (Symlin) also reduces bowel movements more than either drug alone.
Other drug interactions
Dicyclomine adds to the sedating effects of alcohol and other drugs that cause sleepiness such as
- the benzodiazepine class of anti-anxiety drugs (for example, diazepam [Valium], lorazepam [Ativan], clonazepam [Klonopin], alprazolam [Xanax]),
- the narcotic class of pain medications and derivatives (for example, Percocet, Vicodin, Dilaudid, codeine, propoxyphene [Darvon]),
- the tricyclic class of antidepressants (for example, amitriptyline, imipramine [Tofranil, Tofranil-PM], desipramine [Norpramin]), and
- certain antihypertensive medications (for example, clonidine [Catapres], propranolol [Inderal]).
Quick GuideIBS - Irritable Bowel Syndrome: Symptoms, Diet, Treatment
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