dicyclomine, Bentyl (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
Dicyclomine adds to the sedating effects of alcohol and other drugs that cause sleepiness such as the benzodiazepine class of anti-anxiety drugs (for example, diazepam [Valium], lorazepam [Ativan], clonazepam [Klonopin], alprazolam [Xanax]), the narcotic class of pain medications and derivatives (for example, Percocet, Vicodin, Dilaudid, codeine, propoxyphene [Darvon]), the tricyclic class of antidepressants (for example, amitriptyline, imipramine [Tofranil, Tofranil-PM], desipramine [Norpramin]), and certain antihypertensive medications (for example, clonidine [Catapres], propranolol [Inderal]). Antacids and absorbent anti-diarrhea medications (for example, Kaopectate) can decrease the absorption of dicyclomine. Therefore, doses of antacids or absorbent anti-diarrheals should be separated by at least 2 hours from doses of dicyclomine.
PREGNANCY: There are no adequate studies of the effect of dicyclomine in pregnant women at recommended doses (80-160 mg/day). Observation of women who received dicyclomine (up to 40 mg/day) containing products during the first trimester of pregnancy did not reveal any increased risk of harm to the fetus.
NURSING MOTHERS: Dicyclomine is excreted into breast milk. Since there have been reports of apnea (cessation of breathing) when dicyclomine has been given to children, it should not be used by nursing mothers.
SIDE EFFECTS: Side effects include dry mouth, blurred vision, confusion, agitation, increased heart rate, heart palpitations, constipation, difficulty urinating, and occasionally seizures can occur. Other potential side effects include changes in taste perception, difficulty swallowing, headache, nervousness, drowsiness, weakness, dizziness, impotence, flushing, difficulty falling asleep, nausea, vomiting, rash, bloating, and difficulty breathing.
Reference: FDA Prescribing Information
Medically Reviewed by a Doctor on 4/5/2013
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