Medications and Drugs
GENERIC NAME: DICLOFENAC W/MISOPROSTOL - ORAL TABLET (dye-KLO-fen-ack WITH my-so-PROSS-tull)
BRAND NAME(S): Arthrotec
Warning | Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage
WARNING: This drug must not be used during pregnancy because birth defects and fetal and maternal death have occurred. This drug must not be used in women of childbearing age unless there are no alternatives. When this drug has been used to start labor, or for abortion after the first 3 months of pregnancy, rupture of the uterus could occur. Discuss the risks and benefits with your doctor before using this medication. If a woman must use this medication, four requirements must be met: 1) negative pregnancy test within 2 weeks before starting use of this medication; 2) able to use effective measures to prevent pregnancy (contraception); 3) receive oral and written warnings on the dangers of misoprostol use in women of childbearing age, and the risk of possible birth control failure; 4) must begin use of this drug only on the second or third day of the next normal menstrual period. This medication must not be shared with others.
USES: Diclofenac relieves pain and swelling. Misoprostol protects the stomach from diclofenac's irritating effects. This combination medication is used to treat arthritis in people at high risk of developing stomach ulcers.
HOW TO USE: Take this medication by mouth with food or milk or immediately after a meal as directed. Swallow the tablets whole. Do not chew, crush or dissolve the drug. Take this medication with 6 to 8 ounces (180-240ml) of water. Do not lie down for at least 30 minutes after taking this drug. Take this medication exactly as prescribed. Do not increase the dose or take it more often than prescribed. Maximum benefit comes from continued and routine use. Do not use this only when arthritis flares up or for treating other pain, unless directed to do so by your doctor.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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