diclofenac and misoprostol, Arthrotec (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PRESCRIBED FOR: Arthrotec is used for treating signs and symptoms of rheumatoid arthritis or osteoarthritis in patients at risk for developing ulcers and complications of ulcers due to NSAIDs.

SIDE EFFECTS: Arthrotec has the side effects of diclofenac and misoprostol. The most common side effects are:

Diarrhea and abdominal pain may resolve after 2-7 days. Magnesium containing antacids worsen diarrhea caused by misoprostol. Taking Arthrotec with food and avoiding antacids containing magnesium may reduce the occurrence of diarrhea.

Other important side effects include

  • gastrointestinal ulcers and bleeding;
  • liver dysfunction;
  • severe skin reactions,
  • allergic reactions, and
  • kidney failure.

Severe bronchospasms may occur in patients with aspirin-sensitive asthma. Like other NSAIDS, Arthrotec may cause heart attacks and strokes; accumulation of fluid and worsen heart failure; cause or worsen hypertension and kidney failure.

PRESCRIPTION: Yes

GENERIC AVAILABLE: No

PREPARATIONS: Tablets (diclofenac/misoprostol): Arthrotec 50 (50 mg/200 g), Arthrotec 75 (75 mg/200 g) .

STORAGE: The tablets should be kept at room temperature, 15 C - 30 C (59 F - 86 F).

DOSING: For osteoarthritis the recommended dose is Arthrotec 50 given three times daily. Patients who cannot tolerate this regimen may be treated with Arthrotec 50 or 75 twice daily. The recommended dose for treating rheumatoid arthritis is Arthrotec 50 given 3-4 times daily. If this regimen is not tolerated, Arthrotec 50 or 75 twice a day may be used. Administering Arthrotec twice daily is less effective for preventing ulcers. Taking Arthrotec with food may reduce stomach upset. It is recommended that Arthrotec not be taken with alcohol because of the increased risk for ulcers.

Medically Reviewed by a Doctor on 1/27/2015


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