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- What is diclofenac and misoprostol, and how does it work (mechanism of action)?
- What brand names are available for diclofenac and misoprostol?
- Is diclofenac and misoprostol available as a generic drug?
- Do I need a prescription for diclofenac and misoprostol?
- What are the side effects of diclofenac and misoprostol?
- What is the dosage for diclofenac and misoprostol?
- Which drugs or supplements interact with diclofenac and misoprostol?
- Is diclofenac and misoprostol safe to take if I'm pregnant or breastfeeding?
- What else should I know about diclofenac and misoprostol?
What is the dosage for diclofenac and misoprostol?
For osteoarthritis the recommended dose is Arthrotec 50 given three times daily. Patients who cannot tolerate this regimen may be treated with Arthrotec 50 or 75 twice daily. The recommended dose for treating rheumatoid arthritis is Arthrotec 50 given 3-4 times daily. If this regimen is not tolerated, Arthrotec 50 or 75 twice a day may be used. Administering Arthrotec twice daily is less effective for preventing ulcers. Taking Arthrotec with food may reduce stomach upset. It is recommended that Arthrotec not be taken with alcohol because of the increased risk for ulcers.
Which drugs or supplements interact with diclofenac and misoprostol?
(Please also see the drug information for diclofenac.) Diclofenac is generally used with caution in patients taking blood thinning medications (anticoagulants), such as warfarin (Coumadin), because of the increased risk of bleeding.
Antacids reduce the absorption of misoprostol and may delay absorption of diclofenac. Magnesium-containing antacids worsen misoprostol-associated diarrhea. Therefore, Arthrotec should not be administered with magnesium-containing antacids.
Combining NSAIDs with angiotensin receptor blockers (for example, valsartan [Diovan], losartan [Cozaar], irbesartan [Avapro]) or angiotensin converting enzyme inhibitors (for example, enalapril [Vasotec], captopril [captopril]) in patients who are elderly, volume-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible.
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