diazepam, Valium, Diastat, Acudial, Diastat Pediatric, Diazepam Intensol (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
PREPARATIONS: Tablets: 2, 5 and 10 mg. Oral Solution: 1 mg/ml, 5 mg/ml. Injection Solution: 5 mg/ml. Intramuscular Device: 10 mg/2 ml. Rectal Gel: 2.5, 10 and 20 mg.
DRUG INTERACTIONS: Alcohol or medications that cause sedation may add to the sedative effects of diazepam. Patients taking benzodiazepines should avoid such combinations. The following drugs may prolong the effects of diazepam by inhibiting liver enzymes that eliminate diazepam:
Dosages may need to be decreased when these drugs are used with diazepam.
PREGNANCY AND BREASTFEEDING SAFETY: Benzodiazepines, including diazepam, can cause fetal abnormalities and should not be used during pregnancy.
Diazepam is excreted in breast milk and can affect nursing infants. Therefore, diazepam should not be used by women who are nursing.
STORAGE: Diazepam should be stored at room temperature, 15 C to 30 C (59 F to 86 F).
DOSING: Diazepam may be taken with or without food. Diazepam is disposed of by the liver and excreted mainly by the kidney. Dosages of diazepam may need to be lowered in patients with abnormal kidney function. The usual oral diazepam dose for anxiety or seizures is 2-10 mg given 2-4 times daily. The usual rectal dose is 0.2-0.5 mg/kg and depends on the age of the patient.
DRUG CLASS AND MECHANISM: Diazepam is an oral medication that is used to treat anxiety. It belongs to the benzodiazepine family of drugs, the same family that includes alprazolam (Xanax), clonazepam (Klonopin), lorazepam (Ativan), flurazepam (Dalmane), and others. Diazepam and other benzodiazepines act by enhancing the effects of gamma-aminobutyric acid (GABA) in the brain. GABA is a neurotransmitter (a chemical that nerve cells use to communicate with each other) that inhibits activity in the brain. It is believed that excessive activity in the brain may lead to anxiety or other psychiatric disorders. The FDA approved diazepam in November 1963.
Medically reviewed by Eni Williams, PharmD
Reference: FDA Prescribing Information
Medically Reviewed by a Doctor on 3/29/2016
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