Dhea

Are there any interactions with medications?



Anastrozole (Arimidex)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body changes DHEA to estrogen in the body. Anastrozole (Arimidex) is used to help lower estrogen levels in the body. Taking DHEA along with anastrozole (Arimidex) might decrease the effectiveness of anastrozole (Arimidex). Do not take DHEA if you are taking anastrozole (Arimidex).



Exemestane (Aromasin)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body changes DHEA to estrogen in the body. Exemestane (Aromasin) is used to help decrease estrogen in the body. Taking DHEA along with exemestane (Aromasin) might decrease the effectiveness of exemestane (Aromasin). Do not take DHEA if you are taking exemestane (Aromasin).



Fulvestrant (Faslodex)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some types of cancer are affected by hormones in the body. Estrogen-sensitive cancers are cancers that are affected by estrogen levels in the body. Fulvestrant (Faslodex) is used for this type of cancer. DHEA might increase estrogen in the body and decrease the effectiveness of fulvestrant (Faslodex) for treating cancer. Do not take DHEA if you are taking fulvestrant (Faslodex).



Insulin
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Insulin is used to lower blood sugar. Insulin can also lower the amount of DHEA in the body. By lowering DHEA in the body, insulin might lower the effectiveness of DHEA supplements.



Letrozole (Femara)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some types of cancer are affected by hormones in the body. Estrogen-sensitive cancers are cancers that are affected by estrogen levels in the body. Letrozole (Femara) is used for this type of cancer. DHEA might increase estrogen in the body and decrease the effectiveness of letrozole (Femara) for treating cancer. Do not take DHEA if you are taking letrozole (Femara).



Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the liver. DHEA might decrease how quickly the liver breaks down some medications. Taking DHEA along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking DHEA, talk to your healthcare provider if you are taking any medications that are changed by the liver.

Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.



Tamoxifen (Nolvadex)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some types of cancer are affected by hormones in the body. Estrogen-sensitive cancers are cancers that are affected by estrogen levels in the body. Tamoxifen (Nolvadex) is used to help treat and prevent these types of cancer. DHEA increases estrogen levels in the body. By increasing estrogen in the body, DHEA might decrease the effectiveness of tamoxifen (Nolvadex). Do not take DHEA if you are taking tamoxifen (Nolvadex).



Triazolam (Halcion)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down triazolam (Halcion) to get rid of it. DHEA might decrease how quickly the body breaks down triazolam (Halcion). Taking DHEA along with triazolam (Halcion) might increase the effects and side effects of triazolam (Halcion).



Medications for inflammation (Corticosteroids)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

The body naturally makes DHEA. Some medications for inflammation might decrease how much DHEA the body makes. Taking some medications for inflammation might decrease the effects of taking DHEA pills.

Some medications for inflammation include dexamethasone (Decadron), hydrocortisone (Cortef), methylprednisolone (Medrol), prednisone (Deltasone), and others.

Dosing considerations for Dhea.

The following doses have been studied in scientific research:

BY MOUTH:
  • In postmenopausal women and in elderly men: Doses of 25-50 mg daily are commonly used.
  • For treatment of schizophrenia: Increasing doses of DHEA of 25 mg daily for 2 weeks, 25 mg two times daily for 2 weeks, and 50 mg two times daily for 2 weeks.
  • For replacement of hormones when the adrenal glands are not working well (androgen deficiency): 25-50 mg given daily as a single dose.
  • For systemic lupus erythematosus (SLE): 200 mg per day along with conventional medical treatment, but doses up to 600 mg per day have been used.
  • For improving bone mineral density in people with weak bones (osteoporosis): 50-100 mg per day.
  • For erectile dysfunction: 50 mg per day.

Therapeutic Research Faculty copyright

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