dexamethasone injection (Baycadron, Decadron [Discontinued], Dexamethasone Intensol) (cont.)

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STORAGE: Dexamethasone should be stored as intact vials at room temperature, between 20 C to 25 C (68 F to 77 F). Protect from light and heat. Do not freeze. If diluted, use within 24 hours.

PRESCRIBED FOR: Dexamethasone injection is prescribed for vomiting, as well as for a variety of diseases where blocking the immune system is important. This includes allergies, skin conditions, endocrine, hematologic, inflammatory, neoplastic, nervous system, renal, respiratory, rheumatic, and autoimmune diseases. It is also used to manage cerebral edema and chronic swelling.

DOSING: The dose for dexamethasone is based on whether is administered intravenously or by intramuscular injection as well as the severity of the condition requiring treatment. Consult the official prescribing information for dosing regimens.

DRUG INTERACTIONS: Dexamethasone may decrease levels of drugs that are broken down by liver enzymes. Examples include abiraterone, apixaban (Elquis), aripiprazole (Abilify), boceprevir (Victrelis), dronedarone (Multaq), and quetiapine (Seroquel, Seroquel XR) . Consider increasing the dose of the drug or avoiding this combination altogether. Adverse effects, such as bone marrow suppression, are enhanced when dexamethasone is used with other immunosuppressants such as leflunomide (Arava) and tacrolimus (Prograf). Dosing schedules should be evaluated and alternative therapies should be considered. Live vaccines should also be avoided because dexamethasone reduces immune function.

Medically Reviewed by a Doctor on 5/30/2014

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