Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.
Ketoconazole (Nizoral, Extina, Xolegel, Kuric) may reduce the breakdown of desvenlafaxine, therefore increasing
concentrations of desvenlafaxine in the body and the risk of adverse effects.
Desvenlafaxine may reduce the concentration of midazolam (Versed).
PREGNANCY: There are no adequate studies of desvenlafaxine in
pregnant
women.
NURSING MOTHERS: Desvenlafaxine is secreted in breast milk. Mothers
who are taking desvenlafaxine should consider not
breastfeeding.
SIDE EFFECTS: Desvenlafaxine can cause nausea,
headaches, anxiety,
insomnia, drowsiness, constipation, weakness, dry mouth, sweating, diarrhea and
loss of appetite. Increased blood pressure can occur and should be monitored.
Seizures have been reported. Sexual dysfunction (decreased sex drive and delayed
orgasm and ejaculation) has been associated with desvenlafaxine. Some patients
may experience withdrawal reactions upon stopping desvenlafaxine. Symptoms of
withdrawal include anxiety, nausea, nervousness, and insomnia. The dose of
desvenlafaxine should be gradually reduced when therapy is discontinued to
prevent symptoms of withdrawal.
Antidepressants increased the risk of suicidal thinking and behavior
(suicidality) in short-term studies in children and adolescents with depression
and other psychiatric disorders. Anyone considering the use of desvenlafaxine or
any other antidepressant in a child or adolescent must balance this risk with
the clinical need. Patients who are started on therapy should be closely
observed for clinical worsening, suicidality, or unusual changes in behavior.
Depression is an illness that involves the body, mood, and thoughts and affects the way a person eats and sleeps, the way one feels about oneself, and the way one thinks about things. The principal types of depression are major depression, dysthymia, and bipolar disease (also called manic-depressive disease).
Post-traumatic stress disorder (PTSD), a psychiatric condition, can develop after any catastrophic life event. Symptoms include nightmares, flashbacks, sweating, rapid heart rate, detachment, amnesia, sleep problems, irritability, and exaggerated startle response. Treatment may involve psychotherapy, group support, and medication.
Childhood depression can interfere with social activities, interests, schoolwork and family life. Symptoms and signs include anger, social withdrawal, vocal outbursts, fatigue, physical complaints, and thoughts of suicide. Treatment may involve psychotherapy and medication.
Dysthymia is a less severe form of chronic depression. Symptoms and signs include insomnia, suicidal thoughts, guilt, empty feeling, loss of energy, helplessness, sluggishness, and persistent aches and pains. Treatment may involve psychotherapy, electroconvulsive therapy, and antidepressants.
Postpartum depression is a form of depression that occurs within a year after delivery. It is thought that rapid hormone changes after childbirth may lead to depression. Symptoms of postpartum depression include crying a lot, headaches, chest pains, eating too little or too much, sleeping too little or too much, withdrawal from friends and family, and feeling irritable, sad, hopeless, worthless, guilty, and overwhelmed. Treatment typically involves talk therapy and medication.
Depression in teenagers may be caused by many factors. Symptoms of teen depression include apathy, irresponsible behavior, sadness, sudden drop in grades, withdrawal from friends, and alcohol and drug use. Treatment of depression in adolescents may involve psychotherapy and medications.
Depression in the elderly is very common. That doesn't mean, though, it's normal. Treatment may involve antidepressants, psychotherapy, or electroconvulsive therapy.
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