PRESCRIBED FOR: Desvenlafaxine is used for the treatment of major depression.
DOSING: The recommended dose of desvenlafaxine is 50 mg daily, with or without food. Tablets should be taken whole and should not be crushed, divided, chewed, or dissolved. Doses greater than 50 mg are not more effective but cause more side effects.
DRUG INTERACTIONS: All SNRIs, including desvenlafaxine, should not be taken with any of the monoamine oxidase inhibitor (MAOI) class of antidepressants, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl), and procarbazine (Matulane) or other drugs that inhibit monoamine oxidase [for example, linezolid (Zyvox)]. Such combinations may lead to confusion, high blood pressure, tremor, hyperactivity, coma, and death. Desvenlafaxine should not be administered within 14 days after stopping MAOIs and MAOIs should not be administered within 7 days of stopping desvenlafaxine.
Similar reactions may occur if desvenlafaxine is combined with other SNRIs, selective serotonin reuptake inhibitors (for example, fluoxetine [Prozac] or paroxetine [Paxil]) or other drugs that increase serotonin in the brain, for example, tryptophan, St. John's wort, meperidine (Demerol) or tramadol (Ultram).
Quick GuidePhysical Symptoms of Depression in Pictures
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