- What is desvenlafaxine (Pristiq), and how does it work (mechanism of action)?
- What brand names are available for desvenlafaxine (Pristiq)?
- Is desvenlafaxine (Pristiq) available as a generic drug?
- Do I need a prescription for desvenlafaxine (Pristiq)?
- What are the side effects of desvenlafaxine (Pristiq)?
- What is the dosage for desvenlafaxine (Pristiq)?
- Which drugs or supplements interact with desvenlafaxine (Pristiq)?
- Is desvenlafaxine (Pristiq) safe to take if I'm pregnant or breastfeeding?
- What else should I know about desvenlafaxine (Pristiq)?
What is the dosage for desvenlafaxine (Pristiq)?
The recommended dose of desvenlafaxine is 50 mg daily, with or without food. Tablets should be taken whole and should not be crushed, divided, chewed, or dissolved. Doses greater than 50 mg are not more effective but cause more side effects.
Which drugs or supplements interact with desvenlafaxine (Pristiq)?
: All SNRIs, including desvenlafaxine, should not be taken with any of the monoamine oxidase inhibitor (MAOI) class of antidepressants, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl), and procarbazine (Matulane) or other drugs that inhibit monoamine oxidase [for example, linezolid (Zyvox)]. Such combinations may lead to confusion, high blood pressure, tremor, hyperactivity, coma, and death. Desvenlafaxine should not be administered within 14 days after stopping MAOIs and MAOIs should not be administered within 7 days of stopping desvenlafaxine.
Similar reactions may occur if desvenlafaxine is combined with other SNRIs, selective serotonin reuptake inhibitors (for example, fluoxetine [Prozac] or paroxetine [Paxil]) or other drugs that increase serotonin in the brain, for example, tryptophan, St. John's wort, meperidine (Demerol) or tramadol (Ultram).
SNRIs may increase the effect of warfarin (Coumadin), leading to excessive bleeding. Warfarin therapy should be monitored more frequently in patients who are also taking desvenlafaxine. Combining SNRIs with aspirin, nonsteroidal antiinflammatory drugs (NSAIDs) or other drugs that affect bleeding may increase the likelihood of upper gastrointestinal bleeding.
Ketoconazole (Nizoral, Extina, Xolegel, Kuric) may reduce the breakdown of desvenlafaxine, therefore increasing concentrations of desvenlafaxine in the body and the risk of adverse effects. Desvenlafaxine may reduce the concentration of midazolam (Versed).
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