desvenlafaxine (Pristiq) (cont.)
Ketoconazole (Nizoral, Extina, Xolegel, Kuric) may reduce the breakdown of desvenlafaxine, therefore increasing
concentrations of desvenlafaxine in the body and the risk of adverse effects.
Desvenlafaxine may reduce the concentration of midazolam (Versed).
PREGNANCY: There are no adequate studies of desvenlafaxine in
pregnant
women.
NURSING MOTHERS: Desvenlafaxine is secreted in breast milk. Mothers
who are taking desvenlafaxine should consider not
breastfeeding.
SIDE EFFECTS: Desvenlafaxine can cause nausea,
headaches, anxiety,
insomnia, drowsiness, constipation, weakness, dry mouth, sweating, diarrhea and
loss of appetite. Increased blood pressure can occur and should be monitored.
Seizures have been reported. Sexual dysfunction (decreased sex drive and delayed
orgasm and ejaculation) has been associated with desvenlafaxine. Some patients
may experience withdrawal reactions upon stopping desvenlafaxine. Symptoms of
withdrawal include anxiety, nausea, nervousness, and insomnia. The dose of
desvenlafaxine should be gradually reduced when therapy is discontinued to
prevent symptoms of withdrawal.
Antidepressants increased the risk of suicidal thinking and behavior
(suicidality) in short-term studies in children and adolescents with depression
and other psychiatric disorders. Anyone considering the use of desvenlafaxine or
any other antidepressant in a child or adolescent must balance this risk with
the clinical need. Patients who are started on therapy should be closely
observed for clinical worsening, suicidality, or unusual changes in behavior.
Reference: FDA Prescribing Information
Last Editorial Review: 1/7/2009
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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