desvenlafaxine (Pristiq) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Ketoconazole (Nizoral, Extina, Xolegel, Kuric) may reduce the breakdown of desvenlafaxine, therefore increasing concentrations of desvenlafaxine in the body and the risk of adverse effects. Desvenlafaxine may reduce the concentration of midazolam (Versed).

PREGNANCY: There are no adequate studies of desvenlafaxine in pregnant women.

NURSING MOTHERS: Desvenlafaxine is secreted in breast milk. Mothers who are taking desvenlafaxine should consider not breastfeeding.

SIDE EFFECTS: Desvenlafaxine can cause nausea, headaches, anxiety, insomnia, drowsiness, constipation, weakness, dry mouth, sweating, diarrhea and loss of appetite. Increased blood pressure can occur and should be monitored. Seizures have been reported. Sexual dysfunction (decreased sex drive and delayed orgasm and ejaculation) has been associated with desvenlafaxine. Some patients may experience withdrawal reactions upon stopping desvenlafaxine. Symptoms of withdrawal include anxiety, nausea, nervousness, and insomnia. The dose of desvenlafaxine should be gradually reduced when therapy is discontinued to prevent symptoms of withdrawal.

Antidepressants increased the risk of suicidal thinking and behavior (suicidality) in short-term studies in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of desvenlafaxine or any other antidepressant in a child or adolescent must balance this risk with the clinical need. Patients who are started on therapy should be closely observed for clinical worsening, suicidality, or unusual changes in behavior.

Reference: FDA Prescribing Information


Last Editorial Review: 1/7/2009



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