GENERIC NAME: desvenlafaxine
BRAND NAME: Pristiq, Khedezla
DRUG CLASS AND MECHANISM: Desvenlafaxine is an oral drug that is used for treating depression. It is in a class of antidepressant drugs called selective serotonin and norepinephrine reuptake inhibitors (SNRI); a class that also contains venlafaxine (Effexor) and duloxetine (Cymbalta). (Desvenlafaxine is an active metabolite of venlafaxine, that is, it is a product of venlafaxine that is manufactured by the body from venlafaxine.) Desvenlafaxine affects neurotransmitters, the chemicals that nerves within the brain make and release in order to communicate with each other. Neurotransmitters either travel across the space between nerves and attach to receptors on the surface of nearby nerves or they attach to receptors on the surface of the nerves that produced them, to be taken up by the nerve and released again (a process referred to as re-uptake).
Many experts believe that an imbalance among neurotransmitters is the cause of depression. Serotonin and norepinephrine are two neurotransmitters released by nerves in the brain. Desvenlafaxine works by preventing the reuptake of serotonin and epinephrine by nerves after they have been released. Since uptake is an important mechanism for removing released neurotransmitters and terminating their actions on adjacent nerves, the reduced uptake caused by desvenlafaxine increases the effect of serotonin and norepinephrine in the brain. The FDA approved desvenlafaxine in February 2008.
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets (extended release): 50 and 100 mg
STORAGE: Tablets should be kept at room temperature, 20 C and 25 C (68 F and 77 F).
Quick GuideDepression Hurts: Physical Symptoms of Depression
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Use the pill identifier tool on RxList.