desmopressin acetate (DDAVP, Stimate, Minirin) (cont.)

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Medical and Pharmacy Editor:

DOSING:

Central diabetes insipidus:

  • Adults and children 12 years of age and older: Initiate with 0.05 mg by mouth every 12 hours, may titrate up to 0.1 to 1.2 mg divided every 8 to 12 hours.
  • Children of 4 years to under 12 years of age: Initiate with 0.05 mg by mouth every 12 hours, may titrate up to 0.1 to 0.8 mg divided every 8 to 12 hours.
  • The intranasal dose for adults and children older than 12 years old is 10 to 40 mcg per day or divided and given in 2 or 3 doses (every 8 or 12 hours). The dose for children 3 months to 12 years is 5 to 30 mcg daily or divided and given every 12 hours.
  • The intravenous dose for adults and children older than 12 years of age is 2 to 4 mcg daily. Children 3 months to 12 years old should receive 0.1-1 mcg per day or divided and given every 12 hours.

Primary nocturnal enuresis:

  • Adults and children 6 years of age and older: 0.1 to 0.2 mg orally at bedtime. (May increase up to 0.6 mg if necessary)

DRUG INTERACTIONS: Desmopressin should be used with caution with drugs tricyclic antidepressants, selective-serotonin reuptake inhibitors, NSAIDs, lamotrigine (Lamictal, Lamictal CD, Lamictal ODT, Lamictal XR), and opiate analgesics due to increased risk of water intoxication with extremely low sodium levels.

PREGNANCY: There are no adequate studies done on Desmopressin to determine safe and effective use in pregnant women.

NURSING MOTHERS: Desmopressin may be distributed in breast milk; however, there are no adequate studies done to determine infant risk. It should be used with caution by nursing mothers.

SIDE EFFECTS: Side effects of Desmopressin are headache, fatigue, rhinitis, abdominal pain, and conjunctivitis (pink eye). Changes in blood pressure, low sodium levels, and increased heart rate may occur.

REFERENCE: DDAVP Prescribing Information.


Medically Reviewed by a Doctor on 6/2/2014


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