desmopressin acetate (DDAVP, Stimate, Minirin)

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GENERIC NAME: desmopressin acetate

BRAND NAME: DDAVP, Stimate, Minirin

DRUG CLASS AND MECHANISM: Desmopressin is a man-made analogue of vasopressin which is the body's natural anti-diuretic hormone released by the pituitary. It works by increasing water permeability in renal tubular cells, which decreases urine volume and increases urine concentration. In people with diabetes insipidus due to trauma or surgery in the pituitary region of the brain, it reduces frequent urination and thirst. The FDA approved desmopressin in February 1978.



PREPARATIONS: Tablets: 0.1 mg and 0.2 mg; Nasal Spray: 0.01 mg/ml and 1.5 mg/ml; Injection: 4 mcg/ml.

STORAGE: Store desmopressin tablets and spray at room temperature 20 C to 25 C (68 F 77 F). Refrigerate that injection at 2 C to 8 C (36 F to 46 F).

PRESCRIBED FOR: Desmopressin tablets are used for central diabetes insipidus and management of frequent thirst and urination, following head trauma or surgery to the pituitary region. Desmopressin is also used for primary nocturnal enuresis, also known as bedwetting.

Medically Reviewed by a Doctor on 6/2/2014

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