- What is desipramine, and how does it work (mechanism of action)?
- What brand names are available for desipramine?
- Is desipramine available as a generic drug?
- Do I need a prescription for desipramine?
- What are the side effects of desipramine?
- What is the dosage for desipramine?
- Which drugs or supplements interact with desipramine?
- Is desipramine safe to take if I'm pregnant or breastfeeding?
- What else should I know about desipramine?
What is the dosage for desipramine?
The usual adult dose is 100-200 mg at bedtime or divided every 12 hours. The maximum dose is 300 mg daily.
Which drugs or supplements interact with desipramine?
: Desipramine interacts with other medications and drugs that slow the brain's function, such as alcohol, barbiturates, benzodiazepines, for example, lorazepam (Ativan), diazepam (Valium), temazepam (Restoril), oxazepam (Serax), clonazepam (Klonopin) as well as zolpidem (Ambien) and narcotics. Reserpine has a stimulatory effect on patients taking TCAs.
Desipramine and other TCAs should not be used with monoamine oxidase inhibiting drugs, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane) since high fever, convulsions and even death can occur when these drugs are used together.
Cimetidine (Tagamet) can increase desipramine blood levels, possibly causing side effects. Other drugs which can increase disipramine blood levels include propafenone (Rythmol), flecainide (Tonocard), quinidine (Quinidex, Quinaglute), and fluoxetine (Prozac).
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