desipramine, Norpramin (cont.)

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DOSING: The usual adult dose is 100-200 mg at bedtime or divided every 12 hours. The maximum dose is 300 mg daily.

DRUG INTERACTIONS: Desipramine interacts with other medications and drugs that slow the brain's function, such as alcohol, barbiturates, benzodiazepines, for example, lorazepam (Ativan), diazepam (Valium), temazepam (Restoril), oxazepam (Serax), clonazepam (Klonopin) as well as zolpidem (Ambien) and narcotics. Reserpine has a stimulatory effect on patients taking TCAs.

Desipramine and other TCAs should not be used with monoamine oxidase inhibiting drugs, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane) since high fever, convulsions and even death can occur when these drugs are used together.

Cimetidine (Tagamet) can increase desipramine blood levels, possibly causing side effects. Other drugs which can increase disipramine blood levels include propafenone (Rythmol), flecainide (Tonocard), quinidine (Quinidex, Quinaglute), and fluoxetine (Prozac).

TCAs may inhibit the antihypertensive effect of clonidine (Catapres). Therefore, combining TCAs with clonidine may lead to dangerous elevations in blood pressure.

PREGNANCY: There are no adequate studies of desipramine in pregnant women.

NURSING MOTHERS: Desipramine is secreted in breast milk and the effect on nursing infants is known. Nursing should be avoided while taking desipramine.

Medically Reviewed by a Doctor on 9/12/2014


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