- Understanding Depression Slideshow
- Take the Depression Quiz
- Depression Tips Slideshow
- Depression FAQs
- Patient Comments: Depression - Treatments
- Patient Comments: Depression - Therapy
- Patient Comments: Depression - Symptoms in Teens
- Find a local Psychiatrist in your town
- Depression facts
- What is a depressive disorder? Depression vs. sadness
- What are myths about depression?
- What are the types of depression, and what are depression symptoms and signs?
- Depression symptoms and signs in men
- Depression symptoms and signs in women
- Depression symptoms and signs in teenagers
- Depression symptoms and signs in children
- What are the risk factors and causes of depression?
- Postpartum depression
- What specialists treat depression?
- What tests do health-care professionals use to diagnose depression?
- What treatments are available for depression?
- What is the general approach to treating depression?
- What about sexual dysfunction related to antidepressants?
- What about discontinuing antidepressants?
- What are complications of depression?
- What is the prognosis for depression?
- Is it possible to prevent depression?
- What about self-help and home remedies for depression?
- How can someone help a person who is depressed?
- Where can one seek help for depression?
- What is in the future for depression?
- Where can people find more information about depression?
Quick GuideLearn to Spot Depression: Symptoms, Warning Signs, Medication
What about discontinuing antidepressants?
Antidepressants should be gradually tapered and should not be abruptly discontinued. Abruptly stopping an antidepressant in some patients can cause discontinuation syndrome.
For example, abruptly stopping an SSRI such as paroxetine can cause dizziness, nausea, flu-like symptoms, body aches, anxiety, irritability, fatigue, and vivid dreams. These symptoms typically occur within days of abrupt cessation, and can last one to two weeks (up to 21 days). Among the SSRIs, paroxetine and fluvoxamine cause more pronounced discontinuation symptoms than fluoxetine, sertraline, citalopram, escitalopram, vortioxetine, and vilazodone. Some patients experience discontinuation symptoms despite gradual tapering of the SSRI. Abrupt cessation of venlafaxine, duloxetine, desvenlafaxine, or levomilnacipran can cause discontinuation symptoms similar to those of SSRIs.
Abruptly stopping MAOIs can lead to irritability, agitation, and delirium. Similarly, abruptly stopping a TCA can cause agitation, irritability, and abnormal heart rhythms.
What are complications of depression?
Depression can have a significant impact on the structure and function of many parts of the brain. This can result in many negative consequences. For example, people with severe depression are at higher risk of suffering from anxiety, chronic depression, other emotional issues, or having more medical problems or chronic pain. People with a chronic illness, such as diabetes and heart disease, who also have depression tend to have worse outcome of their medical illness.