Dementia (cont.)
What Are the Risk Factors for Dementia?
Researchers have identified several risk factors that affect the likelihood
of developing one or more kinds of dementia. Some of these factors are
modifiable, while others are not.
Age. The risk of AD,
vascular dementia, and several other dementias goes up
significantly with advancing age.
Genetics/family history. As described in the section "What Causes Dementia?"
researchers have discovered a number of genes that increase the risk of
developing AD. Although people with a family history of AD are generally
considered to be at heightened risk of developing the disease themselves, many
people with a family history never develop the disease, and many without a
family history of the disease do get it. In most cases, it is still impossible
to predict a specific person's risk of the disorder based on family history
alone. Some families with CJD, GSS, or fatal familial insomnia have mutations in
the prion protein gene, although these disorders can also occur in people
without the gene mutation. Individuals with these mutations are at significantly
higher risk of developing these forms of dementia. Abnormal genes are also
clearly implicated as risk factors in Huntington's disease, FTDP-17, and several
other kinds of dementia. These dementias are described in the section "What are
the different kinds of dementia?"
Smoking and alcohol use. Several recent studies have found that smoking
significantly increases the risk of mental decline and dementia. People who
smoke have a higher risk of atherosclerosis and other types of vascular disease,
which may be the underlying causes for the increased dementia risk. Studies also
have found that drinking large amounts of alcohol appears to increase the risk
of dementia. However, other studies have suggested that people who drink
moderately have a lower risk of dementia than either those who drink heavily or
those who completely abstain from drinking.
Atherosclerosis. Atherosclerosis is the buildup of plaque - deposits of
fatty substances, cholesterol, and other matter - in the inner lining of an artery.
Atherosclerosis is a significant risk factor for vascular dementia, because it
interferes with the delivery of blood to the brain and can lead to stroke.
Studies have also found a possible link between atherosclerosis and AD.
Cholesterol. High levels of low-density lipoprotein (LDL), the so-called bad
form of cholesterol, appear to significantly increase a person's risk of
developing vascular dementia. Some research has also linked high cholesterol to
an increased risk of AD.
Plasma homocysteine. Research has shown that a higher-than-average blood level of homocysteine
- a type of amino acid - is a strong risk factor for the
development of AD and vascular dementia.
Diabetes. Diabetes is a risk
factor for both AD and vascular dementia. It is also a known risk factor for
atherosclerosis and stroke, both of which
contribute to vascular dementia.
Mild cognitive impairment. While not all people with mild cognitive
impairment develop dementia, people with this condition do have a significantly
increased risk of dementia compared to the rest of the population. One study
found that approximately 40 percent of people over age 65 who were diagnosed
with mild cognitive impairment developed dementia within 3 years.
Down syndrome. Studies have found that most people with
Down syndrome develop
characteristic AD plaques and neurofibrillary tangles by the time they reach
middle age. Many, but not all, of these individuals also develop symptoms of
dementia.
Next: How Is Dementia Diagnosed? »
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