delavirdine 200 mg tablet - oral, Rescriptor (cont.)
PRECAUTIONS: Before taking delavirdine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems.To decrease your risk of spreading HIV disease to others, always use an effective barrier method (latex or polyurethane condoms/dental dams) during all sexual activity. Consult your doctor or pharmacist for more details.During pregnancy, this medication should be used only when clearly needed. However, HIV medicines are now usually given to pregnant women with HIV. Treatment has been shown to decrease the risk of HIV transmission to the baby. Delavirdine may be part of that treatment. Discuss the risks and benefits with your doctor.It is not known if delavirdine passes into breast milk. Because breast milk can transmit HIV, do not breast-feed.
DRUG INTERACTIONS: See also How to Use section.The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.Some products that may interact with this drug include: drugs that decrease the amount of acid in your stomach (for example, ulcer drugs/heartburn relievers such as H2 blockers including cimetidine/famotidine, proton pump inhibitors such as omeprazole/lansoprazole).Other medications can affect the removal of delavirdine from your body, which may affect how delavirdine works. Examples include some drugs used to treat seizures (such as carbamazepine, phenobarbital, phenytoin), macrolide antibiotics (such as clarithromycin), rifamycins (such as rifabutin, rifampin), St. John's wort, among others.Delavirdine can slow down the removal of many other medications from your body, which may affect how they work. Examples of affected drugs include antiarrhythmics (such as quinidine), cisapride, some drugs for anxiety/sleep (such as alprazolam, midazolam, triazolam), drugs to treat erectile dysfunction (such as sildenafil), ergot drugs (such as ergotamine), pimozide, cholesterol-reducing statins (such as atorvastatin, fluvastatin, lovastatin, simvastatin), trazodone, warfarin, among others.Some other drugs to treat HIV infection (including protease inhibitors such as indinavir, ritonavir) may also interact with delavirdine. Your doctor will adjust your medications and monitor your treatment to reduce the risk of side effects.This document does not contain all possible drug interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems.
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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