PRESCRIBED FOR: Delavirdine is used together with other anti-HIV drugs for the treatment of HIV infection.
SIDE EFFECTS: The most common side effects of delavirdine are:
Other important side effects include
- difficulty sleeping,
- abdominal cramps, and
- muscle pain.
GENERIC AVAILABLE: No
PREPARATIONS: Tablets: 100 and 200 mg
STORAGE: Delavirdine should be stored at room temperature, 15 C to 30 C (59 F to 86 F).
DOSING: The recommended dose for adults is 400 mg three times daily. To administer as a solution four 100 mg tablets in at least 3 oz of water should stand for a few minutes. It then shoud be mixed and consumed in its entirety immediately. Delavirdine may be administered without regard to meals since food does not reduce its absorption.
DRUG INTERACTIONS: Delavirdine has many drug interactions because it reduces the activity of certain liver enzymes that breakdown many drugs, and the breakdown of delavirdine is reduced by other drugs.
Some examples of delavirdine interactions include:
- Rifampin (Rifadin), rifabutin (Mycobutin), saquinavir (Invirase), anticonvulsants (for example, phenytoin [Dilantin], carbamazepine [Tegretol], phenobarbitol) decrease blood concentrations of delavirdine and should not be combined with delavirdine since decreased blood concentrations may reduce the effectiveness of delavirdine. Antacids and didanosine (Videx) also decrease blood concentrations of delavirdine. Therefore, the administration of delavirdine with antacids or didanosine should be separated by at least one hour.
- Clarithromycin (Biaxin), ketoconazole (Nizoral) and fluoxetine (Prozac) increase blood concentrations of delavirdine, and this can cause increased side effects from delavirdine.
- Delavirdine increases the blood concentration of indinavir (Crixivan), saquinavir (Invirase), warfarin (Coumadin), quinidine (Cardioquin, Quinaglute), clarithromycin (Biaxin), benzodiazepines (for example, diazepam [Valium], lorazepam [Ativan]), nifedipine (Adalat, Procardia), lovastatin (Mevacor, Altoprev), simvastatin (Zocor), pimozide (Orap), and ergot derivatives (for example, ergonovine, ergotamine, methlyergonovine). Administration of delavirdine with these agents could increase the risk of serious side effects from these agents. Delavirdine should not be combined with lovastatin, simvastatin, pimozide, ergot derivatives, Valium, and Ativan.
- St. John's wort also should not be combined with delavirdine because it may reduce the effect of delavirdine by decreasing its blood levels.
- Delavirdine may increase blood levels of warfarin, leading to an increased risk of bleeding.
PREGNANCY: The are no adequate studies of the use of delavirdine in pregnant women.
NURSING MOTHERS: It is not known whether delavirdine is secreted in breast milk. HIV infected mothers should not nurse their infants because of the risk of transmitting HIV to an infant that is not infected.
Reference: FDA Prescribing Information
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