Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.
STORAGE: Delavirdine should be stored at room temperature, 15 C to 30 C (59 F to 86 F).
PRESCRIBED FOR: Delavirdine is used together with other anti-HIV drugs for the treatment of HIV infection.
DOSING: The recommended dose for adults is 400 mg three times daily. To administer as a solution four 100 mg tablets in at least 3 oz of water should stand for a few minutes. It then shoud be mixed and consumed in its entirety immediately. Delavirdine may be administered without regard to meals since food does not reduce its absorption.
DRUG INTERACTIONS: Delavirdine has many drug interactions because it reduces the activity of certain liver enzymes that breakdown many drugs, and the breakdown of delavirdine is reduced by other drugs.
Some examples of delavirdine interactions include:
Rifampin (Rifadin), rifabutin (Mycobutin),
saquinavir (Invirase), anticonvulsants (for
example, phenytoin [Dilantin],
carbamazepine [Tegretol], phenobarbitol) decrease blood concentrations of delavirdine and should not be combined with delavirdine since decreased blood concentrations may reduce the effectiveness of delavirdine. Antacids and didanosine (Videx) also decrease blood concentrations of delavirdine. Therefore, the administration of delavirdine with antacids or didanosine should be separated by at least one hour.
Delavirdine increases the blood concentration of
indinavir (Crixivan), saquinavir (Invirase),
quinidine (Cardioquin, Quinaglute), clarithromycin (Biaxin),
benzodiazepines (for example,
nifedipine (Adalat, Procardia),
(Zocor), pimozide (Orap), and ergot derivatives (for example, ergonovine, ergotamine, methlyergonovine). Administration of delavirdine with these agents could increase the risk of serious side effects from these agents. Delavirdine should not be combined with lovastatin, simvastatin, pimozide, ergot derivatives, Valium, and Ativan.
St. John's wort
also should not be combined with delavirdine because it may reduce the effect of delavirdine by decreasing its blood levels.
Delavirdine may increase blood levels of warfarin, leading to an increased risk of bleeding.