dasatinib, Sprycel (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Certain drugs decrease the concentration of dasatinib resulting in decreased blood levels and possibly reduced effect. Examples include dexamethasone, carbamazepine, phenobarbital, rifampin, phenobarbital, and St John's Wort. A dose increase should be considered if dasatinib is combined with such drugs.

Drugs that reduce production of acid in the stomach reduce the absorption of dasatinib. Examples include proton pump inhibitors (PPIs) such as omeprazole (Prilosec) and H2 blocking drugs such as famotidine (Pepcid). Antacids used 2 hours before or after administration of dasatinib are reasonable alternatives to drugs that reduce the production of acid in the stomach.

Dasatinib increases the blood concentration of simvastatin (Zocor) by reducing the activity of enzymes that break down simvastatin in the liver. This may increase the side effects of simvastatin. Dasatinib may interact with other drugs that are broken down in a similar way as simvastatin.

PREGNANCY: Dasatinib is harmful to the fetus and should not be used during pregnancy.

NURSING MOTHERS: It is unknown whether dasatinib is excreted in human milk.

Medically reviewed by Eni Williams, PharmD


Medically Reviewed by a Doctor on 6/17/2015


Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.


Back to Medications Index