dasatinib (Sprycel) Leukemia Drug Side Effects, Drug Interactions, Dosing

dasatinib, Sprycel (cont.)

Pharmacy Author:

Omudhome Ogbru, PharmD

Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

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Medical and Pharmacy Editor:

Jay W. Marks, MD

Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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PREGNANCY: Dasatinib is harmful to the fetus and should not be used during pregnancy.

NURSING MOTHERS: It is unknown whether dasatinib is excreted in human milk.

SIDE EFFECTS: Common side effects include fluid retention, headache, diarrhea, constipation, weakness, nausea and vomiting, abdominal distention, weight loss or gain, rash, itching, chills, dizziness, and muscle pain. Serious side effects include fever associated with reduced white blood cells, reduced platelets, and red blood cell counts, infection, stomach or intestinal bleeding, bleeding in the brain, heart failure, and fluid in the lungs.