Other important and serious side effects of dasatinib include:
- fever associated with reduced white blood cells,
- reduced platelets,
- reduced blood cell counts,
- stomach or intestinal bleeding,
- bleeding in the brain,
- heart failure, and
- fluid in the lungs.
GENERIC AVAILABLE: No
PREPARATIONS: Tablets: 20, 50, 70, 80, 100, and 140 mg
STORAGE: Dasatinib should be stored at room temperature between 15 C - 30 C (59 F -86 F).
PRESCRIBED FOR: Dasatinib is used for the treatment of newly diagnosed Philadelphia chromosome positive (Ph+) chronic myeloid leukemia (CML); treatment of chronic, accelerated, or myeloid or lymphoid blast phase Ph+ CML with resistance or intolerance to prior therapy including imatinib; and treatment of Ph+ acute lymphoblastic leukemia (ALL) with resistance or intolerance to prior therapy.
DOSING: The recommended dose range of dasatinib is 100-180 mg orally once daily. For newly diagnosed Ph+ CML treatment starts at 100 mg and is increased to 140 mg daily as needed. For advanced Ph+ CML or Ph+ ALL treatment is started at 140 mg and increased to 180 mg daily as needed.
DRUG INTERACTIONS: The blood concentration of dasatinib may be increased by several drugs that reduce its break down by liver enzymes. Increased blood concentrations of dasatinib may increase the occurrence of adverse effects. Examples include ketoconazole, itraconazole (Sporanox), clarithromycin (Biaxin), atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), saquinavir (Invirase), telithromycin (Ketek), voriconazole (Vfend), and grapefruit juice. A dose reduction should be considered if there are no alternative medications that will not interact with dasatinib, for example a reduction in dose from 100 mg to 20 mg or 140 mg to 40 mg daily.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Use the pill identifier tool on RxList.