darunavir, TMC-114 (Prezista)

Type of Drug: Protease Inhibitor

Once HIV has infected a cell and made copies of itself, it uses an enzyme called protease to process itself correctly so it can be released from the cell to infect other cells. Protease inhibitors work by blocking that enzyme.

Approved adult dosing

For those who have taken antiretroviral drugs before: one 600 mg tablet Prezista + one 100 mg capsule Norvir, two times a day

  • Morning

Picture of the HIV treatment drug Prezista (darunavir, TMC-114) 600 mg capsule

Prezista 600 mg

+

Picture of HIV medication Norvir 100 mg capsules

Norvir

  • Evening

Picture of the HIV treatment drug Prezista (darunavir, TMC-114) 600 mg capsule

Prezista 600 mg

+

Picture of HIV medication Norvir 100 mg capsules

Norvir

For those who have NEVER taken antiretroviral drugs: two 400 mg tablets Prezista + one 100 mg capsule Norvir, once a day

Picture of the HIV treatment drug Prezista (darunavir, TMC-114) 400 mg capsule

Prezista 400 mg

+

Picture of HIV medication Norvir 100 mg capsules

Norvir

Note: Prezista has been available as a 300 mg tablet (dose is two 300 mg tablets + one 100 mg capsule Norvir, two times a day), but this is being phased out.

Notes on taking this medication

  • Must take Prezista with Norvir; it is approved only with the use of Norvir
  • Must take with food
  • Prezista interacts with many other drugs; persons using Prezista with those drugs may need an adjustment to their dose of Prezista or the other drugs; consult your medical provider

Side effects

SOURCE: United States Department of Veterans Affairs. "Drug Dosing Toolkit, Prezista (darunavir, TMC-114)."
<http://www.hiv.va.gov/vahiv?page=treat-drug-Prezista>


Last Editorial Review: 2/5/2010 3:03:34 PM




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