dalteparin (Injection; Fragmin) (cont.)

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DOSING: To prevent blood clots in immobile patients at risk for clots or high risk patients undergoing abdominal surgery or hip replacement, the dose is 5000 units subcutaneously (SQ) once daily. In low risk abdominal surgery patients, the dose is 2500 units SQ once daily. To treat clots in cancer patients, the dose is 200 units per kg weight SQ once daily (max 18,000 units) for month 1, followed by 150 units per kg weight SQ once daily (max 18,000 units) during months 2 to 6. To treat clots in unstable angina or heart attack, the dose is 120 units per kg weight (max 10,000 units) every 12 hours.

DRUG INTERACTIONS: Combining dalteparin with other blood thinning agents may increase the risk of severe bleeding. Dalteparin should not be combined with urokinase or other anticoagulants such as apixaban (Eliquis), dabigatran (Pradaxa) and rivaroxaban (Xarelto). Therapy should be monitored when used with platelet inhibitors (such as aspirin and clopidogrel [Plavix]), serotonin reuptake inhibitors (such as sertraline [Zoloft] and fluoxetine [prozac, Sarafem, Prozac Weekly]), and nonsteroidal anti-inflammatory drugs (such as ibuprofen). Dalteparin may increase potassium levels, so caution with and monitoring of potassium levels is advised with drugs such as ACE inhibitors (for example, lisinopril [Zestril, Prinivil]), angiotensin II receptor blockers (for example, losartan [Cozaar]), and other drugs like aliskiren, spironolactone (Aldactone), eplerenone, and potassium salts.

Medically Reviewed by a Doctor on 9/28/2015

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