dalteparin (Injection; Fragmin) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PREGNANCY: Adverse effects were not observed in animal studies, as LMWHs do not cross the placenta. LMWHs are preferred over unfractionated heparin and warfarin (Coumadin) in women who are pregnant. Agents should be discontinued at least 24 hours before planned delivery.

NURSING MOTHERS: Dalteparin enters breast milk, though oral absorption by the infant is extremely low. The effect of this low level of exposure on the infant is unknown.

SIDE EFFECTS: The most frequent adverse reactions include bleeding, drop in platelet count, bruising, pain at injection site, and increase in liver function tests. An immune reaction resulting in a drop in platelets and clotting (heparin-induced thrombocytopenia) is very rare, and significantly lower than with heparin use. LMWHs should be avoided in patients with epidural or spinal punctures as there is significant risk of spinal or epidural hematomas resulting in paralysis.

REFERENCE: FDA Prescribing Information.


Medically Reviewed by a Doctor on 5/20/2014


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