- What is dalteparin injection, and how does it work (mechanism of action)?
- What brand names are available for dalteparin injection?
- Is dalteparin injection available as a generic drug?
- Do I need a prescription for dalteparin injection?
- What are the side effects of dalteparin injection?
- What is the dosage for dalteparin injection?
- Which drugs or supplements interact with dalteparin injection?
- Is dalteparin injection safe to take if I'm pregnant or breastfeeding?
- What else should I know about dalteparin injection?
What is dalteparin injection, and how does it work (mechanism of action)?
Dalteparin is a low molecular weight heparin (LMWH) similar to enoxaparin (Lovenox) and tinzaparin. Dalteparin is used to treat or prevent blood clots and their complications (deep vein thrombosis or DVT and pulmonary embolism or PE). Deep vein thrombosis is the formation of blood clots in veins deep in a muscle, most often in the legs. Deep vein thrombosis may lead to pulmonary embolism, a condition in which a piece of the clot (the embolus) breaks loose and travels through the veins to the lung. In the lung the clot blocks an artery and prevents the part of the lung that is supplied by the artery from working normally. If the artery that is blocked is a large artery, the embolus can cause sudden death. Patients undergoing hip replacement and other major surgery are at increased risk of deep vein thrombosis and pulmonary embolism. Dalteparin, like other LMWHs is derived from breaking heparin into smaller units. Dalteparin prevents clot formation by accelerating the breakdown of clotting factors Xa and IIa (thrombin) by antithrombin III. Unfractionated heparin, unlike LMWHs, also breaks down clotting factors IX, XI, XII, and plasmin. Unlike heparin, the effect of dalteparin does not need to be monitored with blood tests. The FDA approved dalteparin in December 1994.
What brand names are available for dalteparin injection?
Is dalteparin injection available as a generic drug?
GENERIC AVAILABLE: No
Do I need a prescription for dalteparin injection?
What are the side effects of dalteparin injection?
The most frequent adverse reactions are:
- drop in platelet count,
- pain at injection site, and
- increase in certan factors inliver function tests.
An immune reaction resulting in a drop in platelets and clotting (heparin-induced thrombocytopenia) is very rare, and significantly lower than with heparin use. LMWHs should be avoided in patients with epidural or spinal punctures as there is significant risk of spinal or epidural hematomas resulting in paralysis.
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