dabigatran (Pradaxa)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is dabigatran, and how does it work (mechanism of action)?

  • Dabigatran is an oral drug used to treat and prevent blood clots (an anticoagulant or blood thinner) in the hearts of patients with atrial fibrillation. These clots are likely to break into pieces and travel to the brain to cause strokes.
  • Similarly, it is used to treat and prevent blood clots in the deep veins of the legs (deep venous thrombosis or DVT) and blood clots in the lungs. Blood clots in the deep veins of the legs are likely to break into pieces and travel to the lungs to block arteries in the lungs (pulmonary embolus or PE). Dabigatran works by blocking the action of thrombin a protein that is necessary for the coagulation of blood that results in blood clots. Reducing the action of thrombin reduces the ability of blood to clot.
  • Dabigatran was approved by the FDA on October 2010.

What brand names are available for dabigatran?

Pradaxa

Is dabigatran available as a generic drug?

GENERIC AVAILABLE: No

Do I need a prescription for dabigatran?

Yes

What are the uses for dabigatran?

What are the side effects of dabigatran?

Common side effects of dabigatran include:

Other serious side effects include:

  • The most serious side effect is major bleeding. Major bleeding includes hemorrhagic stroke, intracranial hemorrhage, fatal bleeding, and gastrointestinal bleeds.
  • Dabigatran increases the risk of bleeding and can cause significant and, sometimes, fatal bleeding. All signs or symptoms of blood loss such as a drop in hemoglobin and/or hematocrit or low blood pressure should be evaluated and dabigatran should be discontinued in patients with active bleeding.
Medically Reviewed by a Doctor on 1/11/2016

Quick GuideAtrial Fibrillation: Heart Symptoms, Diagnosis, & Afib Treatment

Atrial Fibrillation: Heart Symptoms, Diagnosis, & Afib Treatment
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