Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.
Cyproheptadine also can intensify the drying effects on moist tissues (such
as the eye or mouth) of other medications with anticholinergic properties (for
example, dicyclomine [Bentyl] and bethanechol [Urecholine], probanthine).
PREGNANCY AND BREASTFEEDING SAFETY: Studies in pregnant women have not shown that cyproheptadine harms
the fetus during the first, second and third trimesters of pregnancy. However,
these studies do not exlude the possibility of harm. Cyproheptadine should be
used during pregnancy only if it is clearly needed. It is not known whether cyproheptadine is excreted in human
STORAGE: Cyproheptadine should be stored at room temperature, 15 C - 30 C (59
F - 86 F).
The recommended starting dose for adults is 4 mg every 8 hours.
dose range is 4 mg to 20 mg daily.
Some patients may require up to 32 mg day.
The dose should not exceed 0.5 mg/kg daily.
Children 7 to 14 years of age should receive 4 mg 3 times daily. The maximum
dose is 16 mg daily.
Children 2 to 6 years old are treated with 2 mg three times daily and the
maximum dose is 12 mg a day.
The total daily dose may also be calculated by
weight (0.25 mg/kg/day) or surface area (8 mg/m2).
DRUG CLASS AND MECHANISM:
Cyproheptadine is an oral antihistamine used for
treating allergic reactions.
It works by blocking the effects of histamine and
is classified as a first generation antihistamine.
Histamine is released by cells of the body during several types of allergic
reactions and, to a lesser extent, during some viral infections, such as the
When the histamine binds to receptors on other cells, it stimulates
changes within the cells that lead to the release of chemicals that cause
sneezing, itching, and increased production of mucus. Antihistamines compete
with histamine for cell receptors and bind to the receptors without stimulating
the cells. In addition, they prevent histamine from binding and stimulating the
Cyproheptadine also blocks the action of acetylcholine (anticholinergic
effect) and serotonin, two neurotransmitters that nerves and muscles use to
communicate with one another, and it causes drowsiness.