Periactin (cyproheptadine)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What are the adverse events and side effect of Periactin?

Side effects of include:

Other side effects that have been reported include:

Antihistamines may reduce mental alertness, however, they may occasionally produce excitation in children.

Patients should be warned about driving a car or operating machinery and participating in other activities that require mental alertness and motor coordination.

Antihistamines may add to the sedative effects of alcohol, hypnotics, sedatives, tranquilizers, and anti-anxiety drugs.

Antihistamines are more likely to cause dizziness, sedation, and hypotension (low blood pressure) in elderly patients.

What is the dosage for Periactin, and how should I take it?

  • The recommended starting dose for adults is 4 mg every 8 hours.
  • The dose range is 4 mg to 20 mg daily.
  • Some patients may require up to 32 mg day. The dose should not exceed 0.5 mg/kg daily.
  • The dosage for children 7 to 14 years of age should receive 4 mg 3 times daily. The maximum dose is 16 mg daily.
  • Children 2 to 6 years old are treated with 2 mg three times daily and the maximum dose is 12 mg a day.
  • The total daily dose may also be calculated by weight (0.25 mg/kg/day) or surface area (8 mg/m2).
Medically Reviewed by a Doctor on 5/4/2017

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