cyclophosphamide (Cytoxan)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Is cyclophosphamide safe to take if I'm pregnant or breastfeeding?

  • Use of cyclophosphamide during pregnancy may affect the fetus. Fetuses exposed to cyclophosphamide may be born with missing fingers, toes and a poorly-developed heart. Cyclophosphamide should not be administered during pregnancy.
  • Cyclophosphamide is excreted in breast milk and could cause serious problems in the nursing infant.

What else should I know about cyclophosphamide?

What preparations of cyclophosphamide are available?

  • Powder for intravenous injection: 100, 200, 500, 1000, and 2000 mg)
  • Tablets: 25, 50 mg.

How should I keep cyclophosphamide stored?

  • Powder and tablets should be stored at room temperature, 15 C - 30 C (59 F - 86 F).
  • Solutions prepared with bacteriostatic water are usable up to 24 hours if stored at room temperature and up to 6 days if stored in the refrigerator.
  • DOSING: The usual initial dose of cytoxan for adults and children is 40-50 mg/kg administered intravenously over 2-5 days in divided doses. This dose may repeated at 2-4 week intervals. The usual oral dose is 1-5 mg/kg daily. Subsequent maintenance doses are adjusted based on the response of the tumor to treatment and the side effects.

Reference: FDA Prescribing Information

Medically Reviewed by a Doctor on 6/17/2016

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