OTHER SERIOUS SIDE EFFECTS:
Other serious side effects of cyclophosphamide include:
- Heart failure
- Abnormal heartbeats
- Lung toxicity
- Liver toxicity
- Nerve toxicity
- Powder for intravenous injection: 100, 200, 500, 1000, and 2000 mg)
- Tablets: 25, 50 mg.
Allopurinol (Zyloprim) enhances the ability of cyclophosphamide to reduce production of blood cells from the bone marrow.
Cyclophosphamide increases the occurrence of heart failure that is caused by doxorubicin (Adriamycin), increases the action of blood thinners such as warfarin (Coumadin), and decreases the effectiveness of quinolone antibiotics ciprofloxacin (Cipro, Cipro XR, Proquin XR).
PREGNANCY AND BREASTFEEDING SAFETY:
- Use of cyclophosphamide during pregnancy may affect the fetus. Fetuses exposed to cyclophosphamide may be born with missing fingers, toes and a poorly-developed heart. Cyclophosphamide should not be administered during pregnancy.
- Cyclophosphamide is excreted in breast milk and could cause serious problems in the nursing infant.
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