cyclophosphamide (Cytoxan)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Cancer 101: Cancer Explained

OTHER SERIOUS SIDE EFFECTS:

Other serious side effects of cyclophosphamide include:

PREPARATIONS:

  • Powder for intravenous injection: 100, 200, 500, 1000, and 2000 mg)
  • Tablets: 25, 50 mg.

DRUG INTERACTIONS:

Allopurinol (Zyloprim) enhances the ability of cyclophosphamide to reduce production of blood cells from the bone marrow.

Cyclophosphamide increases the occurrence of heart failure that is caused by doxorubicin (Adriamycin), increases the action of blood thinners such as warfarin (Coumadin), and decreases the effectiveness of quinolone antibiotics ciprofloxacin (Cipro, Cipro XR, Proquin XR).

PREGNANCY AND BREASTFEEDING SAFETY:

  • Use of cyclophosphamide during pregnancy may affect the fetus. Fetuses exposed to cyclophosphamide may be born with missing fingers, toes and a poorly-developed heart. Cyclophosphamide should not be administered during pregnancy.
  • Cyclophosphamide is excreted in breast milk and could cause serious problems in the nursing infant.
Medically Reviewed by a Doctor on 6/17/2016

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