GENERIC NAME: cyclophosphamide
BRAND NAME: None
DISCONTINUED BRAND: Cytoxan in the US
GENERIC AVAILABLE: Yes
- Cyclophosphamide is used alone for the treatment of several types of cancers, but often in combination with other drugs to treat breast cancer, leukemia and ovarian cancer.
- It also is approved for treating nephrotic syndrome (a disease of the kidneys) in children.
- Unapproved uses include the treatment of
SIDE EFFECTS: Side effects of cyclophosphamide include:
- Hair loss
- Mouth sores
- Weight loss
- Stomach pain
- Mouth sores (stomatitis)
- Skin pigmentation
- Nail changes
Cyclophosphamide causes kidney failure, and it also may affect the heart and lungs. Cyclophosphamide suppresses production of blood cells from the bone marrow, including white blood cells (leukopenia), red blood cells (anemia) and platelets (thrombocytopenia). Leukopenia reduces the ability of the body to fight infection, thrombocytopenia impairs the ability of blood to clot, and anemia reduces the ability of blood to carry oxygen. Cyclophosphamide suppresses the immune system which may result in serious and sometimes fatal infections. Severe allergic reactions also may occur. Cyclophosphamide may cause inflammation of the urinary bladder with bleeding (hemorrhagic cystitis). This can result in lower abdominal pain from the bladder, problems urinating due to blood clots, and anemia due to loss of blood.
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