What is the dosage for cyclobenzaprine (Amrix, Fexmid)?
- The recommended dose of cyclobenzaprine dose is 5 or 10 mg three times daily using immediate release tablets or 15 or 30 mg once daily using extended release tablets.
Which drugs or supplements interact with cyclobenzaprine (Amrix, Fexmid)?
- Cyclobenzaprine is chemically related to the tricyclic class of antidepressants, for example, amitriptyline (Elavil, Endep), nortriptyline Pamelor). As such, it should not be taken with or within two weeks of any monoamine oxidase (MAO) inhibitor, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane). High fever, convulsions, and even death can occur when these drugs are used together.
- Cyclobenzaprine interacts with other medications and drugs that slow the brain's processes, such as
Is cyclobenzaprine (Amrix, Fexmid) safe to use during pregnancy or while breastfeeding?
- There are no adequate studies of cyclobenzaprine in pregnant women. However, studies in animals suggest no important effects on the fetus. Cyclobenzaprine therefore can be used in pregnancy if the physician feels that it is necessary.
- It is not known whether cyclobenzaprine is secreted in milk. However, since it is related to the tricyclic antidepressants, some of which are excreted in breast milk, caution is advised in using this medication in women who are breastfeeding.
What else should I know about cyclobenzaprine (Amrix, Fexmid)?
What preparations of cyclobenzaprine (Amrix, Fexmid) are available?
- Tablets: 5 and 10 mg.
- Capsules (Extended Release): 15 and 30 mg.
How should I keep cyclobenzaprine (Amrix, Fexmid) stored?
- Tablets should be stored between 15 C and 30 C (59 F and 86 F).
How does cyclobenzaprine (Amrix, Fexmid) work?
- Cyclobenzaprine relieves muscle spasm when the spasm is due to local problems, that is, in the muscle itself and not in the nerves controlling the muscles. Cyclobenzaprine has no effect on muscle function. Cyclobenzaprine seems to accomplish its beneficial effect through a complex mechanism within the nervous system, probably in the brainstem.
When was cyclobenzaprine (Amrix, Fexmid) approved by the FDA?
- The FDA approved cyclobenzaprine in August 1977.
Reference: FDA Prescribing Information
Quick GuideChronic Pain: Causes and Solutions
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Use the pill identifier tool on RxList.