cyanocobalamin (cont.)

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PREPARATIONS: Cyanocobalamin injection, 1000 mcg/mL

STORAGE: Injection should be stored at 20 C - 25 C (68 F - 77 F).

PRESCRIBED FOR: Cyanocobalamin injection is used to treat vitamin B12 deficiencies due to absorption problems (malabsorption) that may be associated with conditions such as pernicious anemia, folic acid deficiency, fish tapeworm infestation, cancers of the pancreas or bowel, and otherproblems.

DOSING: (dosing may vary with individuals and with clinicians; doses presented here are examples for injection, not for oral or topical use) : Pernicious anemia (lifetime treatment required): 100 mcg intramuscularly or subcutaneously once daily for 6-7 days, followed by the same dose given on alternate days for seven doses, then every 3-4 days for another 2-3 months. Recommended maintenance dose is 100 mcg monthly for life.

For iron deficiency, the recommended dose is 30 mcg intramuscular injection once daily for 5-10 days then 100 to 200 mcg intramuscular injection monthly.

DRUG INTERACTIONS: Chloramphenicol (Chloromycetin) may decrease the effectiveness of cyanocobalamin. Cancer drugs may reduce the response to cyanocobalamin treatment. Use of colchicine (Colcrys) and heavy alcohol intake for longer than 2 weeks may decrease the absorption of vitamin B12.

PREGNANCY: Cyanocobalamin has not been adequately evaluated in pregnant women. However, vitamin B12 is an essential vitamin and requirements are increased during pregnancy.

NURSING MOTHERS: Cyanocobalamin is excreted into human milk and is safe to use while breastfeeding. Vitamin B12 requirements are increased in nursing mothers.

Medically Reviewed by a Doctor on 10/10/2014

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