cyanocobalamine (Cobolin-M, Vitamin B12) (cont.)

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PREPARATIONS: Cyanocobalamine injection, 1000 mcg/mL

STORAGE: Injection should be stored at 20 C - 25 C (68 F - 77 F).

DOSING: (dosing may vary with individuals and with clinicians; doses presented here are examples for injection, not for oral or topical use) : Pernicious anemia (lifetime treatment required): 100 mcg intramuscularly or subcutaneously once daily for 6-7 days, followed by the same dose given on alternate days for seven doses, then every 3-4 days for another 2-3 months. Recommended maintenance dose is 100 mcg monthly for life.

For iron deficiency, the recommended dose is 30 mcg intramuscular injection once daily for 5-10 days then 100 to 200 mcg intramuscular injection monthly.

DRUG INTERACTIONS: Chloramphenicol (Chloromycetin) may decrease the effectiveness of cyanocobalamine. Cancer drugs may reduce the response to cyanocobalamine treatment. Use of colchicine (Colcrys) and heavy alcohol intake for longer than 2 weeks may decrease the absorption of vitamin B12.

PREGNANCY: Cyanocobalamine has not been adequately evaluated in pregnant women. However, vitamin B12 is an essential vitamin and requirements are increased during pregnancy.

NURSING MOTHERS: Cyanocobalamine is excreted into human milk and is safe to use while breastfeeding. Vitamin B12 requirements are increased in nursing mothers.

REFERENCE: FDA Prescribing Information

Medically Reviewed by a Doctor on 10/10/2014

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