cyanocobalamine (Cobolin-M, Vitamin B12)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

View the Fat-Fighting Foods Slideshow

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Cyanocobalamine injection, 1000 mcg/mL

STORAGE: Injection should be stored at 20 C - 25 C (68 F - 77 F).

DOSING: (dosing may vary with individuals and with clinicians; doses presented here are examples for injection, not for oral or topical use) : Pernicious anemia (lifetime treatment required): 100 mcg intramuscularly or subcutaneously once daily for 6-7 days, followed by the same dose given on alternate days for seven doses, then every 3-4 days for another 2-3 months. Recommended maintenance dose is 100 mcg monthly for life.

For iron deficiency, the recommended dose is 30 mcg intramuscular injection once daily for 5-10 days then 100 to 200 mcg intramuscular injection monthly.

DRUG INTERACTIONS: Chloramphenicol (Chloromycetin) may decrease the effectiveness of cyanocobalamine. Cancer drugs may reduce the response to cyanocobalamine treatment. Use of colchicine (Colcrys) and heavy alcohol intake for longer than 2 weeks may decrease the absorption of vitamin B12.

PREGNANCY: Cyanocobalamine has not been adequately evaluated in pregnant women. However, vitamin B12 is an essential vitamin and requirements are increased during pregnancy.

NURSING MOTHERS: Cyanocobalamine is excreted into human milk and is safe to use while breastfeeding. Vitamin B12 requirements are increased in nursing mothers.

REFERENCE: FDA Prescribing Information

Medically Reviewed by a Doctor on 10/10/2014

Quick GuidePortion Control Tips: Lose Weight and Stick to Your Diet

Portion Control Tips: Lose Weight and Stick to Your Diet
FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

RxList Logo

Need help identifying pills and medications?

Use the pill identifier tool on RxList.

Subscribe to MedicineNet's Weight Loss/Healthy Living Newsletter

By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.

Health Solutions From Our Sponsors