cromolyn, Nasalcrom (Discontinued), Intal; Opticrom; Gastrocrom (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
PRESCRIBED FOR: Cromolyn inhaled via nebulizer is used for treating chronic asthma and exercise induced asthma. Cromolyn nasal spray is used for controlling symptoms of allergic rhinitis, a condition in which the lining of the nose swells with fluid ("stuffy nose") and fluid is released into the nasal passages ("runny nose"). In conjunctivitis, cromolyn eye solution controls swelling, tearing, itching, and redness of the eye. The oral solution is used for treating excessive production of mast cells throughout the body.
DOSING: Cromolyn nebulized solution: 20 mg inhaled via nebulizer 2 or 4 times daily. Intranasal spray: Adults and children 2 years of age and older can use one spray in each nostril three or four times daily. If necessary, the dose may be increased to 6 times daily.
Ophthalmic (eye) solution: The usual dose in adults and children 4 years of age and older is one or two drops in each eye 4 to 6 times per day. Relief may be evident within a few days but several weeks of therapy may be required.
Oral concentrate solution: The recommended dose is 200 mg 4 times daily 30 minutes prior to meals.
DRUG INTERACTIONS: No drug interactions have been described with cromolyn.
PREGNANCY: There are no adequate studies in pregnant women.
NURSING MOTHERS: It is not known whether cromolyn is secreted into breast milk.
SIDE EFFECTS: Common side effects include diarrhea, headache, nausea, cough, wheezing, and dry throat. Allergic reactions also can occur. Increased spasm of the breathing tubes (bronchospasm), throat irritation, and cough are the most common side effects from oral inhalation of cromolyn. Taking a beta-adrenergic bronchodilator (for example, albuterol) prior to the cromolyn can prevent these side effects. Cromolyn intranasal spray can produce sneezing and nasal irritation, but these effects generally are short-lived following each application. Use of cromolyn eye drops can produce irritation of the eye. This effect also is generally short-lived.
Reference: FDA Prescribing Information
Last Editorial Review: 3/26/2012
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