Crohn's Disease (cont.)
Budesonide (Entocort EC)
Budesonide (Entocort EC) is a new type of corticosteroid for treating Crohn's
disease. Like other corticosteroids, budesonide is a potent antiinflammatory
medication. Unlike other corticosteroids, however, budesonide acts only via
direct contact with the inflamed tissues (topically) and not systemically. As
soon as budesonide is absorbed into the body, the liver converts it into
inactive chemicals. Therefore, for effective treatment of Crohn's disease,
budesonide, like topical 5-ASA, must be brought into direct contact with the
inflamed intestinal tissue.
Budesonide capsules contain granules that allow a slow release of the drug
into the ileum and the colon. In a double-blind multicenter study (published in
1998), 182 patients with Crohn's ileitis and/or Crohn's disease of the right
colon were treated with either budesonide (9 mg daily) or Pentasa (2 grams twice
daily). Budesonide was more effective than Pentasa in inducing remissions while
the side effects were similar to Pentasa. In another study comparing the
effectiveness of budesonide with corticosteroids, budesonide was not better than
corticosteroids in treating Crohn's disease but had fewer side effects.
Because budesonide is broken down by the liver into inactive chemicals, it
has fewer side effects than systemic corticosteroids. It also suppresses the
adrenal glands less than systemic corticosteroids. Budesonide will be available
as an enema for the treatment of proctitis.
Budesonide has not been shown to be effective in maintaining remission in
patients with Crohn's disease. If used long-term, budesonide also may cause some
of the same side effects as corticosteroids. Because of this, the use of
budesonide should be limited to short-term treatment for inducing
remission. Most budesonide is released in the terminal ileum, it will have its
best results in Crohn's disease limited to the terminal ileum.
It is not known whether budesonide is effective in treating patients with
ulcerative colitis, and it is currently not recommended for the treatment of
ulcerative colitis.
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