Crohn's Disease (cont.)
Adam Schoenfeld, MD
George Y. Wu, MD, PhD
In this Article
How is Crohn's disease different from ulcerative colitis?
While ulcerative colitis causes inflammation only in the colon (colitis) and/or the rectum (proctitis), Crohn's disease may cause inflammation in the colon, rectum, small intestine (jejunum and ileum), and, occasionally, even the stomach, mouth, and esophagus.
The patterns of inflammation in Crohn's disease are different from ulcerative colitis. Except in the most severe cases, the inflammation of ulcerative colitis tends to involve the superficial layers of the inner lining of the bowel. The inflammation also tends to be diffuse and uniform (all of the lining in the affected segment of the intestine is inflamed.)
Unlike ulcerative colitis, the inflammation of Crohn's disease is concentrated in some areas more than others, and involves layers of the bowel that are deeper than the superficial inner layers. Therefore, the affected segment(s) of bowel in Crohn's disease often is studded with deeper ulcers with normal lining between these ulcers.
What are the symptoms of Crohn's disease?
Common symptoms of Crohn's disease include abdominal pain, diarrhea, and weight loss. Less common symptoms include poor appetite, fever, night sweats, rectal pain, and occasionally rectal bleeding. The symptoms of Crohn's disease are dependent on the location, the extent, and the severity of the inflammation. The different subtypes of Crohn's disease and their symptoms are:
Crohn's terminal ileitis and ileo-colitis are the most common types of Crohn's disease. (Ulcerative colitis frequently involves only the rectum or rectum and sigmoid colon at the distal end of the colon. These are called ulcerative proctitis and procto-sigmoiditis, respectively.)
Up to one-third of patients with Crohn's disease may have one or more of the following conditions involving the anal area:
Medically Reviewed by a Doctor on 8/27/2014
Viewers share their comments
Crohn's Disease - Symptoms Question: The symptoms of Crohn's disease can vary greatly from patient to patient. What were your symptoms at the onset of your disease?
Crohn's Disease - Diet Question: What diet changes did you have to make, or continue to make to control the symptoms of your Crohn's disease?
Crohn's Disease - Treatment Question: Describe the various kinds of treatment you've had for Crohn's disease.