Crohn's Disease (cont.)
Adam Schoenfeld, MD
George Y. Wu, MD, PhD
In this Article
Surgery in Crohn's disease
There is no surgical cure for Crohn's disease. Even when all of the diseased parts of the intestines are removed, inflammation frequently recurs in previously healthy intestines months to years after the surgery. Therefore, surgery in Crohn's disease is used primarily for:
Usually, after the diseased portions of the intestines are removed surgically, patients can be free of disease and symptoms for some time, often years. Surgery, when successfully performed, can lead to a marked improvement in a patient's quality of life. In many patients, however, Crohn's disease eventually returns, affecting previously healthy intestines. The recurrent disease usually is located at or near the previous site of surgery. In fact, 50% of patients can expect to have a recurrence of symptoms within four years of surgery. Drugs such as Pentasa or 6-MP have been useful in some patients to reduce the chances of relapse of Crohn's disease after surgery.
There is accumulating evidence in favor of post-operative therapy to delay recurrence in Crohn's disease. There appears to be some benefit of mesalamine in reducing the risk of post-op recurrence for up to 3 years. A recent study has also shown infliximab to be effective in preventing postoperative recurrence after ileocecal resection, though relapse may occur when therapy is stopped5.
Treatment strategies by severity and location of disease
Mild to Moderate Active Disease
Moderate to Severe Disease
Perianal or Fistulizing Disease
Viewers share their comments
Crohn's Disease - Symptoms Question: The symptoms of Crohn's disease can vary greatly from patient to patient. What were your symptoms at the onset of your disease?
Crohn's Disease - Diet Question: What diet changes did you have to make, or continue to make to control the symptoms of your Crohn's disease?
Crohn's Disease - Treatment Question: Describe the various kinds of treatment you've had for Crohn's disease.