- Rheumatoid Arthritis Slideshow Pictures
- Take the RA Quiz
- Joint-Friendly Exercises to Reduce RA Pain Slideshow
- What are Cox-2 inhibitors?
- For which conditions are Cox-2 inhibitors prescribed?
- Which COX-2 inhibitors are available in the United States?
- What are NSAIDs (nonsteroidal anti-inflammatory drugs)?
- NSAIDs vs. COX-2 inhibitors, which is better?
- What are the side effects of COX-2 inhibitors and/or NSAIDs?
- What drugs interact with COX-2 and/or NSAIDs?
Which COX-2 inhibitors are available in the United States?
Celecoxib (Celebrex) is the only COX-2 inhibitor available in the United States. It is available as a generic.
What are NSAIDs (nonsteroidal anti-inflammatory drugs)?
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of drugs that reduce inflammation but are different from steroids, another class of drugs that also reduces inflammation. NSAIDs reduce pain, fever, and swelling and are commonly prescribed for inflammation of the joints (arthritis) and other tissues, such as in tendinitis and bursitis. Examples of NSAIDs include:
- indomethacin (Indocin),
- ibuprofen (Advil, Motrin),
- naproxen (Naprosyn),
- piroxicam (Feldene), and
- nabumetone (Relafen).
NSAIDs are used frequently by millions of individuals for treatment of pain, fever and swelling caused by inflammatory conditions as well as for pain alone. NSAIDs work by blocking the production of prostaglandins, chemical messengers that often are responsible for the pain and swelling of inflammatory conditions.
The side effects of NSAIDs are listed below and are compared and contrasted with those of COX-2 inhibitors.
Quick GuideRheumatoid Arthritis (RA) Symptoms & Treatment
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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