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- What are Cox-2 inhibitors?
- For which conditions are Cox-2 inhibitors prescribed?
- Which COX-2 inhibitors are available in the United States?
- What are NSAIDs (nonsteroidal anti-inflammatory drugs)?
- NSAIDs vs. COX-2 inhibitors, which is better?
- What are the side effects of COX-2 inhibitors and/or NSAIDs?
- What drugs interact with COX-2 and/or NSAIDs?
What are Cox-2 inhibitors?
Prostaglandins are made by two different enzymes, cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). The prostaglandins made by the two different enzymes have slightly different effects on the body. COX-2 inhibitors are NSAIDs that selectively block the COX-2 enzyme and not the COX-1 enzyme. Blocking this enzyme impedes the production of prostaglandins by the COX-2 which is more often the cause the pain and swelling of inflammation and other painful conditions. Because they selectively block the COX-2 enzyme and not the COX-1 enzyme, these drugs are uniquely different from traditional NSAIDs which usually block both COX-1 and COX-2 enzymes.
For which conditions are Cox-2 inhibitors prescribed?
COX-2 inhibitors are used for treating:
- Ankylosing spondylitis
- Juvenile rheumatoid arthritis
- Menstrual cramps (primary dysmenorrhea)
- Acute pain (for example, sports injuries)
- Rheumatoid arthritis
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